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A year ago, in this journal, Zhang and coworkers (Zhang et al., 2005) reported that the gene encoding the enzyme responsible for the synthesis of brain sero-tonin, tryptophan hydroxylase-2 (THP2), exhibited a functional variant associated with major (or unipolar) depression. The variant in question (G1463A) altered a critical amino acid (Arg441His) in the enzyme such that, at least in a transfe...

The Sir2 histone deacetylases are important for gene regulation, metabolism, and longevity. A unique feature of these enzymes is their utilization of NAD(+) as a cosubstrate, which has led to the suggestion that Sir2 activity reflects the cellular energy state. We show that SIRT1, a mammalian Sir2 homologue, is also controlled at the transcriptional level through a mechanism that is specific fo...

In this issue of the Biochemical Journal, Zhang et al. reveal a new strategy for modifying the regulated function of CFTR (cystic fibrosis transmembrane conductance regulator) on the apical surface of epithelial cells. Simply stated, these authors tested the idea that the cAMP-dependent channel activity of CFTR could be effectively enhanced by disruption of a protein-protein interaction which i...

Esophageal cancer (EC) is one of the common cancer in China, account for 16% cancer deaths (He et al., 2011). In 2008, more than half of new cases and deaths of EC worldwide happened in China (Ferlay et al., 2010), and esophageal squamous cell carcinoma (ESCC) was a predominantly pathological type (Lambert and Hainaut, 2007). National average incidence in males of 14.3/105 (He et al., 2011), an...

Demonstrations provide a descriptive medium for specifying robotic tasks. Prior work has shown that robots can acquire a range of complex skills through demonstration, such as table tennis (Mülling et al., 2013), lane following (Pomerleau, 1989), pouring water (Pastor et al., 2009), drawer opening (Rana et al., 2017), and multi-stage manipulation tasks (Zhang et al., 2018). However, the most ef...

The prokaryotic generic name Frondicola Zhang et al. 2007 is illegitimate because it is a later homonym of a fungal genus name Frondicola Hyde, 1992 (Fungi, Ascomycota, Sordariomycetes, Xylariomycetidae, Xylariales, Hyponectriaceae) [Principle 2 and Rule 51b(4) of the Bacteriological Code (1990 Revision)]. It is also questionable whether the genus name can be validly published. Therefore, a new...

The beneficiation process contains a number of links which are closely related to all aspects of the quality of products in a process which has a direct impact on the next one, thus influencing the product quality of all processes. Grinding operations form a critical stage in the middle position of the beneficiation process and is the most important part. Grinding operations here refers to ore ...

In contrast to the Permian period, grylloblattidan insects represent a small portion of the Carboniferous entomofaunas (Cui et al. 2011; Béthoux et al. 2010; Storozhenko 2002). The Xiaheyan locality (Tupo Formation; Ningxia, China) is no exception. The nine species of the family Sinonamuropteridae described by Peng et al. (2005) based on material from this locality, and each represented by a si...