Androgen deficiency syndrome in men is a frequently diagnosed condition associated with clinical symptoms including fatigue, decreased libido, erectile dysfunction, and metabolic syndrome. Serum testosterone concentrations decline steadily with age. The prevalence of androgen deficiency syndrome in men varies depending on the age group, known and unknown comorbidities, and the respective study ...

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...

Prognostic factors for peripheral nervous system (PNS) manifestations in primary Sjögren Syndrome (pSS) are essential predicting and preventing disease-related disability. Given the established relationship between vitamin B12 deficiency pSS, we aimed to investigate predictive value of low concentration Sjögren's induced neuropathy (PN).

Abstract Background Previous reports have demonstrated electrocardiographic and echocardiographic abnormalities consistent with early-stage cardiomyopathy in patients creatine transporter (CrT) deficiency, but cardiac involvement has never been accurately characterized. Purpose To investigate the phenotype associated deficiency a murine transgenic model syndrome (CDS). Methods Wild type CrT−/y ...