Background: Oxidation of hepatocyte mitochondria due to iron overload led injury, elevated Transforming growth factor- β (TGF- β), and fibrosis. Fibrosis starts with stellate cell fibrogenesis activated by chronic injury. Liver fibrosis is the main cause morbidity mortality in overload. Deferasirox an chelation drug serving bind have antifibrotic effect. Aim: To examine effect deferasirox on li...

background: metals such as iron, zinc, and copper are critical and necessary for the survival of all living organisms, whereas xenobiotic metals such as lead, cadmium, mercury, and arsenic have no known biologic role. any metals in high doses can have toxic effects. the aim of this work was to evaluate the hematological changes induced by lead as a toxic metal and characterize the potential eff...

Here, we report that ExSO3H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as colorimetric chemosensor permits detection and quantification Fe3+ in aqueous samples at pH 2–5. In addition, observed fluorescent turn-on response was produced when this allowed to interact with human serum albumin (HSA). This fluorescence quenched pre...

Deferasirox, represents an effective iron chelator drug in lower risk myelodysplastic syndromes. Reduction in oxidative stress is responsible of the hematologic improvement but further explanation may impact on its benefit. Biological and clinical studies are necessary to better define mechanisms of action, assess toxicities, and predicting factors of response.

This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the -1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context.

The editorial by GJ Kontoghiorghes [1] contains significant factual inaccuracies, selectively omits important information about deferasirox and lacks the robust epidemiological methodology typical for analysis of pharmacovigilance data for safety signals. The aim of this letter is to correct these inaccuracies, providing correct information for doctors and patients. Several key references in th...

Background: Metals such as iron, zinc, and copper are critical and necessary for the survival of all living organisms, whereas xenobiotic metals such as lead, cadmium, mercury, and arsenic have no known biologic role. Any metals in high doses can have toxic effects. The aim of this work was to evaluate the hematological changes induced by lead as a toxic metal and characterize the potential eff...

Background: Deferasirox is an orally bioavailable synthetic, tridentate iron chelator that binds iron at a 2:1 ratio. The generic brand for this drug is still not available in Indonesia. We aimed to compare the efficacy between the generic drug and its innovator (Exjade®) by a study of bioequivalence in Indonesia among healthy volunteers. Methods: An open-label, single-dose, two-sequence, rand...