Small intestine submucosa (SIS) has emerged as one of a number of naturally derived extracellular matrix (ECM) biomaterials currently in clinical use. In addition to clinical applications, ECM materials form the basis for a variety of approaches within tissue engineering research. In our preliminary work it was found that SIS can be consistently and reliably made into tubular scaffolds which co...

The retinal extracellular matrix (ECM) provides architectural support, adhesion and signal guidance that controls development. Decellularization of the ECM affords great potential to tissue engineering; however, how structural affects in vitro development, differentiation maturation ocular cells remains be elucidated. Here, mouse porcine retinas were decellularized protein profile analyzed. Ace...

Abstract Background Bone-tendon interface (enthesis) plays a pivotal role in relaxing load transfer between otherwise structurally and functionally distinct tissue types. Currently, decellularized extracellular matrix (DEM) from enthesis provide natural three-dimensional scaffold with tissue-specific orientations of molecules for regeneration, however, the distributions collagen PGs content boo...

BACKGROUND Glutaraldehyde (GA) is a widely used cross-linking agent for improving mechanical properties and resistance to enzymatic degradation of collagenous tissue, but it has several drawbacks such as calcification and cytotoxicity. The aim of this study was to find the alternative effective cross-linking methods to GA. MATERIALS AND METHODS Bovine pericardium was processed with GA with et...

© 2011 The Author Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd doi:10.1111/j.1582-4934.2010.01202.x Malignancy, subglottic stenosis and traumatic injury to the trachea require surgical resection. When short segments are involved, primary re-anastomosis affords excellent results. Longer lesions, involving more than half...