We assessed the effect of the previously uncovered gap junction protein alpha 8 (Gja8) mutation present in spontaneously hypertensive rat - dominant cataract (SHR-Dca) strain on blood pressure, metabolic profile, and heart and renal transcriptomes. Adult, standard chow-fed male rats of SHR and SHR-Dca strains were used. We found a significant, consistent 10-15 mmHg decrease in both systolic and...

Glutathione transferase ζ 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several α-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors. Age-related differences have been suggested in DCA pharmacotoxicology, but no information is availa...

Latitudinal body size clines in animals conforming to Bergmann's rule occur on many continents but isolating their underlying genetic basis remains a challenge. In Drosophila melanogaster, the gene Dca accounts for approximately 5-10% of the natural wing size variation (McKechnie SW, Blacket MJ, Song SV, Rako L, Carroll X, Johnson TK, Jensen LT, Lee SF, Wee CW, Hoffmann AA. 2010. A clinally var...

This paper is devoted to difference of convex functions (d.c.) optimization: d.c. duality, local and global optimality conditions in d.c. programming, the d.c. algorithm (DCA), and its application to solving the trust-region problem. The DCA is an iterative method that is quite different from well-known related algorithms. Thanks to the particular structure of the trust-region problem, the DCA ...

As one of the newest members in Artificial Immune Systems (AIS), the Dendritic Cell Algorithm (DCA) has been applied to a range of problems. These applications mainly belong to the field of anomaly detection. However, real-time detection, a new challenge to anomaly detection, requires improvement on the real-time capability of the DCA. To assess such capability, formal methods in the research o...

An ion thruster discharge cathode assembly (DCA) erosion theory is presented based on near-DCA NSTAR plasma potential measurements and experimental results for propellant flow rate effects on ion number density. The plasma potential structures are utilized in an ion trajectory algorithm to determine the location and angle at the DCA keeper of bombarding ions. These results suggest that the plas...

Recently, we developed a framework, namely Multi-hop TDD CAC and DCA (MTCD), for optimal centralized DCA in multi-hop 4G/4G+ UTRA TDD networks. We also proposed two CAC schemes that use a pre-defined optimization algorithm to ensure that admission is based, to a large extent, on topology maintenance, energy conservation, load balancing, and fairness. In this paper, we address the centralized li...

We examined the effect of hypoxia on apoptosis of human colorectal cancer (CRC) cells in vitro and in vivo. All cell lines tested were susceptible to hypoxia-induced apoptosis. DCA treatment caused significant apoptosis under normoxia in SW480 and Caco-2 cells, but these cells displayed decreased apoptosis when treated with DCA combined with hypoxia, possibly through HIF-1alpha dependent pathwa...

The small, water soluble molecule Dichloroacetate (DCA) is recently arousing lively interests in the field of cancer therapy for it has been shown to be able to inhibit the growth of human tumors acting specifically on the mitochondria of cancer cells without perturbing the physiology of nonmalignant cells. Neuroblastoma was one of the tumor types on which DCA was considered ineffective as it i...

Motivated by a scheduling problem encountered in multicast environments, we study a vertex labelling problem, called Directed Circular Arrangement (DCA), that requires one to find an embedding of a given weighted directed graph into a discrete circle which would minimize the total weighted arc length. Its decision version is already known to be NP-complete when restricted to sparse weighted dir...