Neutrophils are key players of the innate immune system that provide a first line of defense against invading pathogens. However, it is unknown whether neutrophils can interact with dendritic cells (DCs) to modulate adaptive immune responses. We demonstrate that neutrophils strongly cluster with immature DCs and that activated, not resting, neutrophils induce maturation of DCs that enables thes...

We investigated differentiation of CD4 T cells responding to Ag presented by bone marrow-derived dendritic cells (DC) in association with MHC class II (MHC II) molecules. Peptides encapsulated in liposomes opsonized by IgG were taken up by endocytosis. MHC II-peptide-specific T cells responding to this Ag were polarized to a Th1 cytokine profile in a CD40-, CD28-, MyD88-, and IL-12-dependent ma...

Human blood dendritic cells (DCs) hold great potential for use in anticancer immunotherapies. CD1c+ myeloid DCs and plasmacytoid DCs (pDCs) have been successfully utilized in clinical vaccination trials against melanoma. We hypothesize that combining both DC subsets in a single vaccine can further improve vaccine efficacy. Here, we have determined the potential synergy between the two subsets i...

Increased exposure to air pollutants such as diesel exhaust particles (DEP) has been proposed as one mechanism to explain the rise in allergic disorders. However, the immunologic mechanisms by which DEP enhance allergic sensitization and asthma remain unclear. We hypothesized that DEP act as an adjuvant for immature dendritic cell (DC) maturation via its effect on airway epithelial cell-derived...

The corrosion inhibition efficiency of benzimidazole, 2-methylbenzimidazole and 2- aminobenzimidazole for mild steel immersed in 3.5 NaCl solution was investigated by electrochemical impedance spectroscopy EIS at concentration range from 10-5 to 10-2 M of imidazoles and temperature range from 30 to 50°C. In addition, DC polarization was examined to determine inhibition mechanism at concentratio...

This paper explores a configuration for boost half bridge DC-DC converters, connected in parallel at the input and series at the output, such that the converters share the input current and load voltage equally. A stable control scheme has been developed to achieve this objective. In order to verify the effectiveness and stability of control scheme, input-parallel output-series (IPOS) connected...

polarization for au/pb(zr ti )o /yba cu o ferroelectric capacitor has been studied and measured by pulse method. a sequence of pulses with amplitudes varying from 0 to 10 volts in 2 volt steps is applied and a conventional polarization curve is obtained by integrating the charge flow from the polarization switching induced by the voltage ramp. a value of 25?c/cm2 is measured for the saturated p...

Infection of mice with murine cytomegalovirus (MCMV) recapitulates many physiopathological characteristics of human CMV infection and enables studying the interactions between a virus and its natural host. Dendritic cells (DC) are mononuclear phagocytes linking innate and adaptive immunity which are both necessary for MCMV control. DC are critical for the induction of cellular immunity because ...

In this study electrocoagulation (EC) process with sacrificial aluminum anode was used to separate crude oil from synthetic oily wastewater emulsion. A preliminary experimental study was performed to evaluate the most accurate operating parameters, which are then used for the determination of crude oil removal efficiency. The experimental results indicated that electrocoagulation was very e...