Malignant hyperthermia (MH) a rare genetic disorder is often associated with congenital disorders which are not diagnosed preoperatively. The incidence of MH being very low is still potentially a fatal disorder in anesthesia practice. Mortality still remains high despite its complex and demanding management. Reporting of MH and MH-like syndrome when treated timely with Dantrolene Sodium drastic...

The effects of sodium nitroprusside (SNP) in rat cerebellar granular cell culture were investigated in the present study. All doses of the SNP (10, 25, 50, 100, 250, 500 microM) were able to induce cell death compared with control values (p < 0.001 for all groups tested). Interestingly enough, a nonlinear dose-response curve was obtained for SNP-induced neurotoxicity. We also investigated the p...

1. The release of catecholamines (CA) from rat adrenal incubated in vivo in Locke solution was studied. 2. Acetylcholine-induced release of CA and CA release by 56 mM KCl were inhibited by verapamil and lanthanum chloride which block calcium permeability. 3. CA secretion induced by salbutamol or by theophylline was unaffected by either verapamil or lanthanum chloride. 4. Dantrolene-sodium inhib...

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (ATX3; MJD1) protein. In biochemical experiments, we demonstrate that mutant ATX3(exp) specifically associated with the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an intracellular calcium (Ca(2+)) rel...

Abstract Management of refractory status epilepticus is challenging for a neurointensivist consequent to systemic complexities associated with various drugs and modalities involved in its treatment. We report one such case that manifested multiple signs malignant hyperthermia following use isoflurane control seizures. However, the delayed random occurrence negative genetic test raises doubts re...

Darier’s disease (DD) is an autosomal dominant skin disorder characterized by acantholysis and dyskeratosis associated with mutations in ATP2A2 encoding for the sarco/endoplasmic reticulum Ca2+-ATPase pump type 2 (SERCA2), resulting patients being functionally haploinsufficient SERCA2. DD keratinocytes displayed a 1.5-fold increase Ca2+ levels above that observed control keratinocytes. This imb...