Current radiotracers for positron emission tomography imaging of choline metabolism have poor systemic metabolic stability in vivo . We describe a novel radiotracer, [F]fluoromethyl-[1,2-H4]-choline (D4-FCH), that employs deuterium isotope effect to improve metabolic stability. D4-FCH proved more resistant to oxidation than its nondeuterated analogue, [F]fluoromethylcholine, in plasma, kidneys,...

Current radiotracers for positron emission tomography imaging of choline metabolism have poor systemic metabolic stability in vivo. We describe a novel radiotracer, [(18)F]fluoromethyl-[1,2-(2)H(4)]-choline (D4-FCH), that employs deuterium isotope effect to improve metabolic stability. D4-FCH proved more resistant to oxidation than its nondeuterated analogue, [(18)F]fluoromethylcholine, in plas...

Different cytotoxic drugs induce cell death by activating the apoptotic programme; a family of cysteinyl aspartate proteases named caspases has been shown to be involved in the initiation as well as the execution of this kind of cell death. In the present study, cleavage of D4-GDI (Rho-GDI 2), an abundant haemopoietic-cell GDP dissociation inhibitor for the Ras-related Rho family GTPases, was d...

The adhesion molecules involved in the migration and retention of activated effector CD8 T cells in the lung microcirculation and their recruitment into lung tissue are largely unknown. Here, we have analyzed the role of lymphocyte function-associated antigen-1 (LFA-1) and very late antigen-4 (VLA-4) on adhesion of influenza hemagglutinin (HA)-specific CD8 T-cell clone D4 under shear conditions...

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The dispersionless limit of generalized Drinfeld-Sokolov hierarchies associated to primitive regular conjugacy class of Weyl group W (g) is discussed. The map from these generalized Drinfeld Sokolov hierarchies to algebraic solutions to WDVV equations has been constructed. Example of g = D4 and [w] = D4(a1) is considered in details and corresponding Frobenius structure is found.

In this paper, we study modular forms on two simply connected groups of type D4 over Q. One group, Gs, is a globally split group of type D4, viewed as the group of isotopies of the split rational octonions. The other, Gc, is the isotopy group of the rational (non-split) octonions. We study automorphic forms on Gs in analogy to the work of Gross, Gan, and Savin on G2; namely we study automorphic...

The lateral habenula (LHb) is involved in reward and aversion and is reciprocally connected with dopamine (DA)-containing brain regions, including the ventral tegmental area (VTA). We used a multidisciplinary approach to examine the properties of DA afferents to the LHb in the rat. We find that >90% of VTA tyrosine hydroxylase (TH) neurons projecting to the LHb lack vesicular monoamine transpor...

BACKGROUND AND AIMS Oilseed rape (Brassica napus) is an important oil crop worldwide. The aim of this study was to identify the variation in nitrogen (N) efficiency of new-type B. napus (genome A(r)A(r)C(c)C(c)) genotypes, and to characterize some critical physiological and molecular mechanisms in response to N limitation. METHODS Two genotypes with contrasting N efficiency (D4-15 and D1-1) w...