In recent years there has been an increasing interest in toxic reactions to drugs, and a number of these have been reported following the treatment of Wilson's disease with penicillamine, particularly the D-L racemic mixture. Purified L-penicillamine has been shown to be a pyridoxine antimetabolite in rats (Kuchinskas and du Vigneaud, 1957; Kuchinskas, Hovarth, and du Vigneaud, 1957) and more r...

Clinoptilolite is used as an adsorbent to remove heavy metal cations due its function a molecular sieve. This sieve characteristic has made it possible study the efficiency of clinoptilolite and D-Penicillamine in comparative way terms adsorption metals (especially copper) from biological medium. For this purpose, was subjected grinding produce homogenized micronized powder two sizes with d90=7...

An in vitro technique for haemolysing ovine red blood cells with copper sulphate was standardized to induce c 50% haemolysis with 0.5 mM CuSO4 after incubation for 14 h at 38 degrees C. This technique was then applied to test the efficacy of trientine and d-penicillamine in preventing haemolysis. Trientine concentrations of 0.5; 1.0 and 1.5 mM were found to be the most effective (P < 0.05) in r...

Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis. The higher dose did not produce significantly greater therapeutic benefit in the group of patients so treated, although individual patients sometimes improved more. The frequency of rashes, blood dyscrasias, and withdrawals from the trial increased withe dosage. It is c...

We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infilt...

Thirty-eight patients with rheumatoid arthritis in remission on penicillamine were entered into a prospective, randomised, placebo controlled study to determine the effects of gradual penicillamine withdrawal, to find a serological marker capable of predicting relapse, and to assess the effects of reintroduction of penicillamine. 80% of patients attempting gradual penicillamine withdrawal flare...