Systems with both quantitative and qualitative responses are widely encountered in many applications. Design of experiment methods needed when experiments conducted to study such systems. Classic experimental design unsuitable here because they often focus on one type response. In this paper, we develop a Bayesian D-optimal method for continuous binary Both noninformative conjugate informative ...

i ABSTRACT In mixture-process variable experiments, it is common that the number of runs is greater than in mixture-only or process-variable experiments. These experiments have to estimate the parameters from the mixture components, process variables, and interactions of both variables. In some of these experiments there are variables that are hard to change or cannot be controlled under normal...

We study the consistency of parameter estimators in adaptive designs generated by a onestep ahead D-optimal algorithm. We show that when the design space is finite, under mild conditions the least-squares estimator in a nonlinear regression model is strongly consistent and the information matrix evaluated at the current estimated value of the parameters strongly converges to the D-optimal matri...

A mixture experiment, a variant of response surface methodology, was designed to determine the proportion of time to feed broiler starter (23% protein), grower (20% protein), and finisher (18% protein) diets to optimize production and processing variables based on a total production time of 48 d. Mixture designs are useful for proportion problems where the components of the experiment (i.e., le...

Abstract Organic Rankine Cycles transform low-temperature heat from sustainable sources into electrical power. Exploiting the full potential of a source requires optimal combination and working fluid. Today, fluids are commonly pure components. However, mixtures can significantly improve process efficiency due to their favorable temperature-glide during evaporation condensation. In this work, w...

Jeruk nipis merupakan salah satu jenis buah-buahan dikenal dengan kandungan vitamin C yang tinggi dan mengandung senyawa kimia bermanfaat bagi tubuh. Sehingga jeruk dapat diolah menjadi minuman. Minuman olahan minuman dalam bentuk cair maupun serbuk tidak bahan tambahan pangan baik alami sintetik dikemas kemasan siap saji. Tujuan dari penelitian ini adalah untuk mendapatkan formulasi optimal pe...

Abstract Multiple Sclerosis (MS) is one of the most common neurological disorders diagnosed in young adults. there are no current cures for the disease or its underlying causes, some drugs have been developed that can decrease or delay disease progression. Fingolimod is an immunomodulating drug, mostly used for treating multiple sclerosis (MS). It approximately halves the rate of relapse ...

This study aimed to develop fiber-enriched cookies by partially replacing wheat flour (WF) with alternative fiber sources including yellow lentil (YLF), green (GLF), banana powder (BP), and peel (BPP). The ratios of YLF, GLF, WF were identified as 24.5, 10.7, 64.8 % (flour basis), respectively, considering the mixture experimental design for an optimal breaking strength cookies. Four types stud...