Cytotoxic T-cell precursors have been shown to occur in spleens of 2-3-day-old mice. By 12 days after birth, the cytotoxic T-cell response of spleen cells to alloantigens has reached 23-32% of adult levels. Addition of extra T-helper cells did not permit cytotoxic T-cell development in spleen cells from newborn to 2-day-old mice suggesting either a lack of precursors or suppression of precursor...

Lymphocytes derived from animals immunized against alloantigens exhibit in vitro cytotoxicity for target cells carrying the respective isoantigen (1). This cytotoxic activity is mediated by theta-bearing (thymus-derived) lymphocytes (T cells) 1 (2, 3). The accumulated evidence indicates that the cellular immune response to an isoantigen or tumor cell exists concomitantly with isoantibodies secr...

Cytotoxic CD8 + T-cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The aim this study was to investigate CD107a (LAMP-1) on cytotoxic SLE-patients particular with nephritis. Peripheral blood ( n = 31) and healthy controls 21) analyzed for expression CD314 by flow cytometry. Kidney biopsies nephritis patients were investigated presence C107a cells immunohistoc...

Keratinocytes expressing tumor or viral antigens can be eliminated by antigen-primed CD8 cytotoxic T cells. CD4 T-helper cells help induction of CD8 cytotoxic T cells from naive precursors and generation of CD8 T-cell memory. In this study, we show, unexpectedly, that CD4 cells are also required to assist primed CD8 effector T cells in rejection of skin expressing human growth hormone, a neo-se...

Bispecific antibodies (BsAbs) have been developed, with one antigen-binding site coordinated against the CD3 receptor (which activates cytotoxic T lymphocytes) and other specific antigens found on cancer cells (CD19, CD20, CD33, CD123, HER2, epithelial cell adhesion molecule [EpCAM], BCMA, CEA, others) [1].

PURPOSE Cell surface HLA class I molecules present peptides derived from human cellular proteins to T cells. In the present study, we investigated the expression of HLA class I in human pancreatic carcinoma. EXPERIMENTAL DESIGN The expression of HLA class I antigen and the extent of tumor infiltration by T cells were investigated in 46 primary tumors and in 14 metastases of pancreatic cancer ...

We tested two biological properties of a continuously growing mouse cytotoxic T cell line, L4, which is specific for influenza A virus and has been cloned and recloned many times. We previously reported that L4 cells are H-2 restricted and cross-reactive for all type A influenza viruses, whereas they do not recognize type B influenza viruses. They bear Thy-1 and Lyt-2 markers. In the present st...

OBJECTIVE Bronchiectasis (BE) in children is common in some communities including Indigenous children in Australia. Relatively little is known about the nature of systemic inflammation in these children, especially the contribution of specific pro-inflammatory and cytotoxic lymphocyte subsets: T-cells, natural killer (NK) cells and NKT-like cells. We have shown that these cells produce increase...