A well-coordinated process is required to construct a complicated structure like the cell wall, which consists of several elements that must be joined appropriately from various sources inside cell. In order successfully moderate dynamic responses developmental and environmental signals, further complexity necessary. The plasma membrane continually actively transporting sugars, enzymes, other w...

Objective: The deformation ability of erythrocytes is critical for their function and affects mobility in the circulation. To circulate travel through narrow vessels, must continuously alter shape by modifying cytoskeleton, which controls elasticity stability. Erythrocytes lack nuclei other major organelles, thus most known signaling cascades are thought to be inactive these cells. As noncanoni...

Certain diseases can cause axons, the nerve fiber portions of neurons, to form a periodic series bulges. Evidence suggests that these bulges are caused by disruption axon's cytoskeleton, and author describes their formation with model based on continuum mechanics nonlinear elasticity.

The plasma membrane Ca-ATPase (PMCA) plays an essential role in maintaining low cytosolic Ca in resting platelets. During platelet activation PMCA is phosphorylated transiently on tyrosine residues resulting in inhibition of the pump that enhances elevation of Ca. Tyrosine phosphorylation of many proteins during platelet activation results in their association with the cytoskeleton. Consequentl...

In this study, we have examined the relationship between epidermal growth factor (EGF)-induced tyrosine phosphorylation of phospholipase C-gamma 1 (PLC-gamma 1) and its translocation from the cytosol to the Triton X-100-insoluble cytoskeleton fraction in rat hepatocytes. The translocation of PLC-gamma 1 was specific for EGF stimulation, because a similar effect was not observed with insulin or ...

Abstract Epithelial monolayers play an important role in a broad range of physiological and pathological processes, such as embryonic development wound healing. become crowded during cell proliferation growth, however, their mechanical properties entities remain obscure. This paper presents novel efficient method utilizing the structural stiffness matrix-based computational (SMM) to investigate...

Bacteria possess an EF-Tu-based cytoskeleton.This article presents a short review. A number of questions which are not discussed in the former publications can be asked, such as: all bacteria ribosomal protein synthesis system and, hence, also EF-Tu. EF-Tu is produced amount that higher than need for function as translation elogation factor ribsomal synthesis. This tries to answer question rega...

Mechanical forces direct a host of cellular and tissue processes. Although much emphasis has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless be transmitted through the cortical cytoskeleton. Yet how the actin cortex senses and transmits forces and how cytoskeletal proteins interact in response to the forces is poorly understood. Here, by combining molecular...

Human plasma contains naturally occurring autoantibodies to the predominant components of the erythrocyte membrane: band 3 and spectrin bands 1 and 2 of the cytoskeleton. The titer of cytoskeletal plasma autoantibodies increases in various hemolytic conditions, suggesting that opsonization of the cytoskeleton may play an important role in the clearance of hemolyzed (not senescent) erythrocytes ...