Chlormadinone acetate (CMA) and cyproterone acetate have been used in medicaltreatment of human benign prostatic hyperplasia (BPH) or prostatic carcinoma [2,3,8,9]. The atrophic effects of CMA on the prostate of rats and dogs have been previously reported from our laboratory[5,6]. Using spontaneous BPH dogs we found that immunostaining of androgen receptor (AR) in both epithelial and stromal fi...