Replication protein A (RPA) is a heterotrimeric, multi-functional protein that binds single-stranded DNA (ssDNA) and is essential for eukaryotic DNA metabolism. Using heteronuclear NMR methods we have investigated the domain interactions and ssDNA binding of a fragment from the 70 kDa subunit of human RPA (hRPA70). This fragment contains an N-terminal domain (NTD), which is important for hRPA70...

Glioma is the most common and aggressive primary adult brain tumor. Long non-coding RNAs (lncRNAs) have important roles in a variety of biological properties of cancers. Here, we elucidated the function and the possible molecular mechanisms of lncRNA HOTAIR in human glioma U87 and U251 cell lines. Quantitative RT-PCR demonstrated that HOTAIR expression was up-regulated in glioma tissues and cel...

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Accumulating evidence has demonstrated that microRNAs (miRNAs) are involved in multiple processes in cancer development and progression. miR-326 has been identified as a tumor suppressor miRNA in several types of human cancer. However, the specific function of miR-326 and its target the nin one binding protein (NOB1) in colorectal carcinoma (CRC) remains unclear. In the present study, we found ...

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Cystic fibrosis transmembrane conductance regulator (CFTR) and P-glycoprotein (P-gp) are ATP-binding cassette (ABC) transporters that have two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). Defective folding of CFTR lacking phenylalanine 508 (DeltaPhe508) in NBD1 is the most common cause of cystic fibrosis. The Phe508 position seems to be universally important in ABC tr...

The Submillimeter-Wave Technology Laboratory (STL) at the University of Massachusetts Lowell has designed and constructed two high resolution terahertz imaging systems based on 325 GHz and 1.5 THz transceivers. While the systems were originally designed to acquire radar signatures of high fidelity scale models, their high sensitivity and high stability at 325 GHz and 1.5 THz make them novel sys...

because as we saw in Handout #3, the Jacobian emerges when we write the exterior product of the dy’s in terms of the dx’s. We will only concern ourselves with integration of n-forms on manifolds of dimension n. In fact, most of our manifolds will be flat (subsets of R), or surfaces only slightly more complicated than spheres. For example, the Stiefel manifold Vm,n of n by p orthogonal matrices ...