نتایج جستجو برای: cyp1a2
تعداد نتایج: 1781 فیلتر نتایج به سال:
The etiology of recurrent pregnancy loss (RPL) remains unclear, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We examined the relation between RPL and polymorphisms in four genes, human aryl hydrocarbon (Ah) receptor, cytochrome P450 (CYP) 1A1, CYP1A2 and CYP1B1, which are involved in the metabolism of a wide range of environmenta...
4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA adducts of 4-ABP are found in tobacco smokers. In vitro metabolism studies with human and rat liver microsomes have shown that CYP1A2 is primarily responsible for catalyzing N-hydroxylation, the initial ...
Human CYP1A2 is an important drug-metabolizing enzyme, similar in sequence to CYP1A1 but with distinct substrate specificity. We have previously shown that residue 382 affected CYP1A1 and CYP1A2 specificities with alkoxyresorufins. To determine whether this residue is also important for the metabolism of other substrates, we have investigated phenacetin oxidation by single (T124S, T223N, V227G,...
The following comments pertain exclusively to the determination of cytochrome CYP1A2 and not to that of N-acetyltransferase 2. With the help of excellent laboratory work and a logically designed experimental procedure, the authors show the level of reproducibility of two caffeine metabolic ratios by repeat investigations in a number of subjects. Unfortunately, this effort is not very useful bec...
Nabumetone, a widely used nonsteroidal anti-inflammatory drug, requires biotransformation into 6-methoxy-2-naphthylacetic acid (6-MNA), a close structural analog to naproxen, to achieve its analgesic and anti-inflammatory effects. Despite its wide use, the enzymes involved in metabolism have not been identified. In the present study, several in vitro approaches were used to identify the cytochr...
سابقه و هدف: پی پرین آلکالوئید اصلی piper nigrum (فلفل سیاه) فعالیت آنزیم های میکروزومال کبدی را تغییر می دهد. پروب کافئین برای تعیین فعالیت آنزیم cyp1a2 استفاده می شود. آنزیم cyp1a2 از آنزیم های مهم در متابولیسم داروها می باشد که بیش از 13 درصد سیتوکروم های کبدی را تشکیل می دهد. این مطالعه به نقش احتمالی پیش مداوای پی پرین در غلظت کافئین می پردازد. مواد و روشها: این مطالعه به صورت cross over د...
Puerarin, an isoflavone glycoside extracted from Pueraria plants, has various medical functions. Cytochrome P450s (CYPs) are crucial phase I metabolizing enzymes, which have been spotlighted for their effects on drug metabolism. The interaction between puerarin and CYPs (CYP1A2 and CYP2D6) was investigated by fluorescence, UV-Vis and circular dichroism spectroscopies, as well as molecular docki...
سابقه و هدف: اندازه گیری غلظت پلاسمایی کافئین در تعیین سطح فعالیت آنزیم میکروزومال کبدی cyp1a2 کمک کننده می باشد. این مطالعه، به منظور بررسی وضعیت آنزیم فوق با کمک اندازه گیری غلظت بزاقی کافئین پس از مصرف خوراکی(به عنوان پروب) در نمونه ای از افراد داوطلب سالم مازندرانی انجام شد.مواد و روشها: غلظت بزاقی کافئین در 100 داوطلب سالم مازندرانی (82 نفر مرد و 18 نفر زن) در زمانهای 0، 5/0، 2 و 5 ساعت پس...
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