We evaluated the use of two tumour markers Cyfra 21.1 and tissue polypeptide antigen (TPA) for disease monitoring. Assessment of response to WHO criteria was compared to response assessment according to changes in the tumour marker levels. The criteria defined for marker response were a 65% decrease for a partial response and a 40% increase for progressive disease. When response evaluations wit...

Breast cancer is the leading nonhematologic cause of meningeal carcinomatosis (MC), a unusual metastatic site. Its treatment generally relies on intrathecally and/or systematically delivered chemotherapy, combined with radiotherapy or surgery when needed. However, the overall survival (OS) of patients with proven MC is short, generally no longer than 6 months after the diagnosis of MC [1]. A re...

BACKGROUND Lung cancers account for the majority of brain metastases which pose major therapeutic challenges. Biomarkers prognosticating for the development of brain metastases in patients with non-small cell lung cancers (NSCLC) may improve personalized care. Six serum proteomic biomarkers were previously investigated at Memorial Sloan Kettering but their associations with brain metastases wer...