نتایج جستجو برای: cyclooctene

تعداد نتایج: 246  

2018
Jonathan C T Carlson Hannes Mikula Ralph Weissleder

Recent developments in bond cleavage reactions have expanded the scope of bioorthogonal chemistry beyond click ligation and enabled new strategies for probe activation and therapeutic delivery. These applications, however, remain in their infancy, with further innovations needed to achieve the efficiency required for versatile and broadly useful tools in vivo. Among these chemistries, the tetra...

Journal: :Dalton transactions 2012
Titel Jurca Sarah Ouanounou Serge I Gorelsky Ilia Korobkov Darrin S Richeson

The bis(imino)pyridine scaffold provides support for the synthesis and characterization of unique Ag(I) pincer complexes [{ArN=CPh}(2)(NPh)]Ag(+)(OTf)(-) (Ar = 2,5-(t)Bu(2)C(6)H(3)3; 2,6-(i)Pr(2)C(6)H(3) 4). The bonding interactions between the cation-anion and between the bis(imino)pyridine ligand and the Ag centre are presented. Coordination of pyridine, toluene, 2-butyne and cyclooctene to t...

2011
M. Masteri-Farahani P. Eghbali F. Salimi

Covalent grafting of MCM-41 with 3-chloropropyl trimethoxysilane and subsequent reaction respectively with acacdien and complexation with MoO2(acac)2 afforded MoO2acacdien@MCM-41. X-ray diffraction and nitrogen sorption analyses revealed the preservation of the textural properties of the support as well as accessibility of the channel system despite sequential reduction in surface area, pore vo...

2007
Jochen Bautz Peter Comba Carlos Lopez de Laorden Matthias Menzel Gopalan Rajaraman

High-valent iron oxidants are known to be the catalytically active species in heme enzymes, and the last decade has seen similar developments in non-heme-iron biomimetics and biochemistry. 2] Extensive reactivity studies, structural, spectroscopic, and computational work have established {FeOOH} and {Fe=O} as relevant intermediates in catalytic oxygenation processes. The species {Fe=O} has also...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Neal K Devaraj Greg M Thurber Edmund J Keliher Brett Marinelli Ralph Weissleder

There has been intense interest in the development of selective bioorthogonal reactions or "click" chemistry that can proceed in live animals. Until now however, most reactions still require vast surpluses of reactants because of steep temporal and spatial concentration gradients. Using computational modeling and design of pharmacokinetically optimized reactants, we have developed a predictable...

2014
Han Zhang Kevin T. Dicker Xian Xu Xinqiao Jia Joseph M. Fox

Described herein is interfacial bioorthogonal cross-linking, the use of bioorthogonal chemistry to create and pattern biomaterials through diffusion-controlled gelation at the liquid-gel interface. The basis is a rapid (k2 284000 M-1 s-1) reaction between strained trans-cyclooctene (TCO) and tetrazine (Tz) derivatives. Syringe delivery of Tz-functionalized hyaluronic acid (HA-Tz) to a bath of b...

Journal: :Chemical Engineering & Technology 2021

The kinetics of cyclooctene epoxidation with H2O2 by micellar catalysis was studied. As catalyst, an ionic liquid (IL) containing the catalytically active tungstate anion used. IL forms micelles in aqueous phase. It is simply formed dissolving sodium and 1-octyl-3-methylimidazolium tetrafluoroborate [OMIM][BF4] H2O2. For catalysis, a power law kinetic model determined that takes critical micell...

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