The title compound, C20H28O3, known as 'trichodermaerin' [systematic name: (4E)-4,9,15,16,16-penta-methyl-6-oxa-tetra-cyclo-[10.3.1.0(1,10).0(5,9)]hexa-dec-4-ene-7,13-dione], is a diterpene lactone which was isolated from Trichoderma asperellum. The structure has a tetra-cycic 6-5-7-5 ring system, with the cyclo-hexa-none ring adopting a twisted half-chair conformation and the cyclo-pentane rin...

The structures of the diastereomer diketopiperazine dipeptides cyclo(LTyr-LPhe) and cyclo-(DTyr-LPhe) are studied in gas phase using resonance-enhanced two-photon ionization, IR/UV double resonance spectroscopy quantum chemical calculation. Both diastereomers exhibit two conformations, with tyrosine ring folded over DKP phenylalanine extended outwards, or vice versa. differ only slightly by nat...

In this paper we present cyclo-dynamic data flow (CDDF), a new data flow model for real time digital signal processing (DSP) applications. CDDF is an extension of cyclo-static dataflow (CSDF) [1,2] which keeps the interesting properties like analyzability and efficient compile time scheduling, while introducing data dependent control flow to improve the expressivity. The semantics are construct...

We previously reported a successful model for treatment of BW 5147 leukemia in AKR mice by adoptive immunother apy using allogeneic spleen cells from C57BL/6 mice. The leukemia cells were given 3 days before initiation of ther apy. Graft-versus-host reaction was prevented by treatment with spleen cells from a second allogeneic strain (CBA), followed by cyclophosphamide and syngeneic spleen cell...

Axonal damage and demyelination are major determinants of disability in patients with peripheral demyelinating neuropathies. The neurotrophin family of growth factors are essential for the normal development and myelination of the peripheral nervous system (PNS), and as such are potential therapeutic candidates for ameliorating axonal and myelin damage. In particular, BDNF promotes peripheral n...

The title compound, C(20)H(20)O(5), was synthesized from the reaction between 3-methoxysalicaldehyde and 1,3-cyclo-hexa-nedione in the presence of palladium(II) chloride. The two fused xanthene rings and one of the six-membered cyclo-hexane rings adopt envelope conformations, while the other six-membered cyclo-hexane ring is in a chair conformation. The mol-ecular packing is stabilized by weak ...

In the title compound, C(17)H(19)NO(7), the cyclo-pentane ring is in an envelope conformation in which the methyl-ene group forming the flap is cis to the cyclo-propane group. The relative configuration between the 4-nitro-benzo-yloxy substituent on the side chain and the cyclo-propane ring is trans and the methoxy-lmethyl group adopts the expected conformation in which the two O atoms are gauc...

The title compound, C(15)H(23)NO(2)S, contains cyclo-hexyl and ethyl substituents on the sulfonamide N atom and the cyclo-hexyl ring adopts a classic chair conformation. The dihedral angle between the benzene ring plane and the mean plane through the six atoms of the cyclo-hexyl ring is 59.92 (6)°. In the crystal structure, C-H⋯O hydrogen bonds link mol-ecules into sheets extending in the bc pl...