To preserve epithelial barrier function, dying cells are squeezed out of an epithelium by "apoptotic cell extrusion." Specifically, a cell destined for apoptosis signals its live neighboring epithelial cells to form and contract a ring of actin and myosin II that squeezes the dying cell out of the epithelial sheet. Although most apoptotic cells extrude apically, we find that some exit basally. ...

This paper reports on an experimental and finite element analysis (FEA) of the cold extrusion of high-grade (AA1100) aluminium. The influence of die angle, reduction ratio and die land on the extrusion force during the extrusion process was investigated. A forward extrusion die was designed and manufactured for the purpose of the experimental research. Interchangeable elements of the extrusion ...

A series of cyclic Ru-alkylidene catalysts have been prepared and evaluated for their efficiency in ring-expansion metathesis polymerization (REMP). The catalyst structures feature chelating tethers extending from one N-atom of an N-heterocyclic carbene (NHC) ligand to the Ru metal center. The catalyst design is modular in nature, which provided access to Ru complexes having varying tether leng...

Formal proofs, even simple ones, may hide an unexpected intricate combinatorics. We define a new combinatorial invariant, the bridge group of a proof, which encodes the cyclic structure of proofs in the sequent calculus. We compute the bridge groups of two infinite families of proofs and identify them with the Baumslag–Solitar and Gersten groups. We observe that the distortion of cyclic subgrou...

This paper describes a variation to the traditional intrusion detection approach motivated by longstanding challenges and recent trends in information security. Intrusion detection systems have historically focused on the protection of local resources by identifying signs of malicious activity that may help administrators prevent a break-in and limit its effects. Outbound intrusion detection fo...