Activation of cyclic nucleotide-dependent signaling pathways inhibits agonist-induced contraction of most vascular smooth muscles except human umbilical artery smooth muscle (HUASM). This impaired vasorelaxation may contribute to complications associated with preeclampsia, intrauterine growth restriction, and preterm delivery. Cyclic nucleotide-dependent signaling pathways converge at the phosp...

Spider dragline silk has enormous potential for the development of biomimetic fibers that combine strength and elasticity in low density polymers. These applications necessitate understanding how silk reacts to different environmental conditions. For instance, spider dragline silk ;supercontracts' in high humidity. During supercontraction, unrestrained dragline silk contracts up to 50% of its o...

We analyze the evolution of cosmological perturbations in the cyclic model, paying particular attention to their behavior and interplay over multiple cycles. Our key results are: (1) galaxies and large scale structure present in one cycle are generated by the quantum fluctuations in the preceding cycle without interference from perturbations or structure generated in earlier cycles and without ...

cGMP is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic nucleotides, including inosine 3',5'-cyclic monophosphate (cIMP). The present study was designed to determine the role of cIMP in hypoxic contractions of isolated porcine coronary arteries. Vascular responses were examined...

Large, elastic arteries buffer the pressure wave originating in the left ventricle and are constantly exposed to higher amplitudes of cyclic stretch (10%) than muscular arteries (2%). As a crucial factor for endothelial and smooth muscle cell function, cyclic stretch has, however, never been studied in ex vivo aortic segments of mice. To investigate the effects of cyclic stretch on vaso-reactiv...

we investigated contraction to noradrenaline (na) and kc1 and sensitivity of na at the level of larger vessels (thoracic aorta and vena cava; left renal artery and left renal vein; lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal ear vein) in a model devised to mimic heart failure. the model presented here is the rabbit coronary ligation model in w...

The physiological heart rate of rodents is around 4-6 Hz, although a stimulus frequency 1 Hz generally used in isolated cardiomyocytes to study changes the contraction-relaxation cycle cardiac muscle physiology and pathophysiology. Our investigated contraction parameters at 1, 2 4 stimulation, roles ATP protein kinase A (PKA) force-frequency relationship cardiomyocytes. cell intracellular Ca2+ ...

Tungsten trioxide (WO3) films have been coated on indium thin oxide (ITO) conductive glass substrate, using aqueous solution of peroxotungstic acid (PTA) by the sol-gel dip coating method. X-ray diffractometery (XRD) analysis confirmed monoclinic and triclinic structure for the film and powdered WO3 respectively. Fourier transforms infrared spectroscopy (FT-IR) exhibit...