We investigated the roles of cyclic GMP and cyclic AMP in the inhibition of rabbit platelet aggregation and degranulation by two nitrovasodilators, sodium nitroprusside (SNP) and 3-morpholinosydnonimine (SIN-1; the active metabolite of molsidomine), with particular reference to the synergistic interaction of these drugs with prostaglandin E1 (PGE1). Changes in platelet cyclic [3H]GMP and cyclic...

1. A protein was demonstrated in mammalian islets of Langerhans that after purification appeared as a single component possessing both cyclic-AMP (adenosine 3':5'-cyclic monophosphate)-binding and cyclic-AMP-dependent protein phosphokinase activities. 2. The protein had an intrinsic association constant for cyclic AMP of 1.15x10(-8)m, which was similar to the K(m) for cyclic AMP (1.11x10(-8)m) ...

The distribution of protein kinases activated specifically by low concentrations of guanosine 3’,5’-monophosphate (cyclic GMP) or adenosine 3’,5’-monophosphate (cyclic AMP) in various tissues and species of Arthropoda was studied. The Arthropoda were found to represent a rich source of cyclic GMP-dependent protein kinases. The relative levels of cyclic GMP-dependent and cyclic AMP-dependent pro...

We derive a general result concerning cyclic orderings of the elements of a matroid. As corollaries we obtain two further results. The first corollary proves a conjecture of Gonçalves [7], stating that the circular arboricity of a matroid is equal to its fractional arboricity. This generalises a well-known result from Nash-Williams on covering graphs by spanning trees, and a result from Edmonds...

Cyclic arcs (defined by Storme and Van Maldghem, [1994]) and pseudocyclic MDS codes are equivalent objects. We survey known results on the existence of cyclic arcs. Some new results on cyclic arcs in PG(2, q) are also given.

background : nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting regulatory t cells in the host. however, its efficacy is transient. here, we aim to investigate whether cyclic chemoim- munotherapy has therapeutic efficacy against cancer. methods :we examined the efficacy of cyclic chemoimmunotherapy with cyclophos- phamide and adoptively tran...

Cyclic guanosine 3’,5’-monophosphate (cyclic GMP) levels were determined in dog thyroid slices using the protein-binding method. [aH]Guanine incorporation into cyclic GMP was also determined by thin layer chromatography. Basal levels of cyclic GMP in dog thyroid slices were usually 10 to 30 pmoles per g wet tissue. These values were at least lo-fold lower than the cyclic adenosine 3’,5’-monopho...