The purpose of this course-based research study was to examine child and youth care (CYC) students’ attitudes toward the use harm-reduction programs services for high-risk youth. In qualitative interpretive inquiry, an open-ended, scenario-based questionnaire used collect data via email. A non-probability purposive sampling strategy applied recruit 16 CYC student participants. thematic analysis...

Objective. The NORAM (Nonrenal Wegener’s Granulomatosis Treated Alternatively with Methotrexate [MTX]) trial demonstrated that MTX can replace cyclophosphamide (CYC) as remission-inducing treatment for patients with newly diagnosed early systemic antineutrophil cytoplasmic antibody–associated vasculitis. Duration of relapse-free survival was longer among CYC-treated patients than among MTX-trea...

Cyclic peptides are increasingly being shown as powerful inhibitors of fibril formation, and have the potential to be therapeutic agents for combating many debilitating amyloid-related diseases. One such example is a cyclic peptide derivative from the human apolipoprotein C-II, which has the ability to inhibit fibril formation by the fibrillogenic peptide apoC-II(60-70). Using classical molecul...

BACKGROUND/AIMS Although high-flux (HF) dialyzers with enhanced membrane permeability are widely used in current hemodialysis (HD) practice, urea kinetic modeling is still being applied to indicate the adequacy of both low-flux (LF) and HF HD. In comparison with urea (molecular weight, 60 Da) and beta(2)-microglobulin (beta(2)MG, 12 kDa), cystatin C (CyC, 13 kDa) is a larger molecule that has a...

Dry eye is both a common symptom and disease. It known that the ophthalmic emulsion of immunomodulator cyclosporine-A (Cyc-A) has positive effect on this condition but its’ absorption to intraocular tissues limited. Nanosuspension drug formulation aims increase bioavailability. The aim study was develop Cyc-A nanosuspension for better via ocular delivery investigate effectiveness by comparing i...

INTRODUCTION The present study investigated whether rugby small-sided games (SSG) could be an effective alternative to continuous stationary cycling (CYC) training at reducing clinical risk factors associated with the development of type 2 diabetes mellitus (T2DM). METHODS Thirty-three middle-aged (48.6±6.6y), inactive men were randomized into a CYC (n=11), SSG (n=11), or control (CON, n=11) ...

The microwave spectrum of the cyclopropane-ammonia ( CsHs* 14NHs) complex has been observed using a pulsed nozzle, Fourier-transform microwave spectrometer. The spectrum is characteristic of a symmetric top, IS,,= 2668.7 16 l(4), with free internal rotation of the NHs subunit. The spectra of the CsHs*r5NHs, CsDs*r5NHs, and CSHe*‘4NDs isotopomers were also measured. This gives a structure in whi...

More than a quarter century has passed since a landmark trial at the National Institutes of Health (NIH) established pulse intravenous (IV) cyclophosphamide (CYC) and high-dose glucocorticoids as the standard of care for active lupus nephritis (1). In the ensuing years, numerous other conventional and biologic therapies have been proposed and tested, most notably mycophenolate mofetil (MMF) (2)...

Objective Cyclophosphamide (CYC) is used in clinical practice off-label for the induction of remission childhood polyarteritis nodosa (PAN). Mycophenolate mofetil (MMF) might offer a less toxic alternative. This study was undertaken to explore relative effectiveness CYC and MMF treatment randomized controlled trial (RCT). Methods an international, open-label, Bayesian RCT investigate PAN. Eleve...

From the beginning, a primary goal of the Cyc project has been to build a large knowledge base containing a store of formalized background knowledge suitable for supporting reasoning in a variety of domains. In this paper, we will discuss the portion of Cyc technology that has been released in open source form as OpenCyc, provide examples of the content available in ResearchCyc, and discuss the...