Skin cancer represents the most prevalent malignancy worldwide, with non-melanoma skin cancer accounting for one third of all oncological cases in the USA. More specifically, cutaneous squamous cell carcinoma (cSCC) accounts for approximately 20% of all non-melanoma skin cancer cases with an estimate of over 700,000 new cases diagnosed yearly in the USA [1-2]. The most important risk factors im...

Marjolin's ulcers, which are epidermoid carcinomas arising on non-healing scar tissue, may be of various pathological types, including squamous cell carcinoma. The pathogenesis of squamous cell carcinoma arising in an ulcer differs from that of the primary cutaneous squamous cell carcinoma. This squamous cell carcinoma is aggressive in nature, and has a high rate of metastasis. Between January ...

Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis that has been reported in association with certain medications. Recognition of medications trigger PG may help to better understand the pathogenesis condition and provide earlier diagnosis treatment for affected patients. Herein, we report case new-onset following initiation checkpoint inhibitor pembrolizumab metastatic cut...

Bazex syndrome is a rare paraneoplastic dermatosis. The underlying malignancy frequently is squamous cell carcinoma of the upper aerodigestive tract or cervical lymph nodes from an unknown primary site. We report a 63-year-old man with squamous cell carcinoma of cervical lymph nodes from an unknown primary site. He developed a mass on the right side of his neck, cutaneous lesions diagnosed as B...

3. Cherpelis BS, Marcusen C, Lang PG. Prognostic factors for metastasis in squamous cell carcinoma of skin. Deramtol Surg 2002; 28: 268–273. 4. Meyer T, Arndt R, Nindl I et al. Association of human papillomavirus infections with cutaneous tumors in immunosuppressed patients. Transpl Int 2003; 16: 146–153. 5. Hartley BE, Searle AE, Breach NM et al. Aggressive cutaneous squamous cell carcinoma of...

Human papillomavirus (HPV) DNA has been identified in esophageal carcinomas. However, the incidence of HPV varies significantly in different geographical locations. In this study, neoplasms from Turkmen Sahra, a region in Golestan province in northeast part of Iran, with a high incidence of squamous cell carcinoma were analyzed for the presence of HPV DNA. Turkmen Sahra is located in the cancer...

Cutaneous horn has been a source of controversy throughout the history. It evoked interest nearly half millennium before and continues to do so. Cornu cutaneum found be associated with several pre-malignant malignant skin conditions. The conditions commonly include actinic keratoses Bowen’s disease. Uncommonly, it is due presence an underlying squamous cell carcinoma. Thus, effort needed determ...

Introduction: Although cervical carcinoma is common, cutaneous metastasis from this tumor is rare. The reported incidence rates of skin metastasis from cervical cancer range from 0.1% to 1.3%. The major histological subtype of cervical carcinoma is squamous cell carcinoma (SCC), accounting for 75% of cases. The remainder are classified as adenocarcinoma, adenosquamous cell carcinoma, or are of ...