As well as other Multikinase Inhibitors (MKI), Imatinib has been related to cutaneous adverse reactions. The majority of these seem to directly depend on its mechanism of action, namely the inhibition of the physiologic function of cutaneous protein kinases, and appear to be dose dependent. Like other traditional chemotherapy agents, MKI cause alopecia, mucositis and xerosis. Cutaneous findings...

background: the reporting of adverse drug reactions (adrs) by nurses in hospitals is very important.aims: this study was aimed at investigating the impact of an educational intervention to improve adr reporting and whethertrained nurses had better knowledge, attitude, and practice toward adr reporting. materials and methods: a total of 300 nurses in a tertiary care teaching hospital in tehran, ...

background: s. alopecuroides, z. officinale and m. officinalis are used traditionally in the treatment of pain. objective: to evaluate the plants effects in the rat formalin test and their activity on the opioid receptors. methods: each rat was placed individually in a cage for 30 min to get acclimated. then 0.05 ml of 10% formalin was injected subcutaneously into the dorsal surface of the righ...

thrombolytic agents are among the medications that are used widely for the treatment of thromboembolic disorders and myocardial infarction (mi). despite the world-wide availability of newer specific agents, streptokinase (sk) is still the most frequently used medication from this class in iran. hence we conducted this study to review the adverse reactions to this medication which were reported ...

stevens-johnson syndrome (sjs) and toxic epidermal necrolysis (ten) are severe adverse cutaneous reactions to drugs. we describe the case of a 19 year old patient with sjs/ten overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. a cytomegalovirus infection was diagnosed by real time polymerase chain reaction (rt-pcr) detection on bronchoalveo...