A 23-year-old man presented with progressive difficulty walking since childhood. Examination showed pes cavus, hammer toes, and peroneal atrophy (Figure 1). Electroneuromyography revealed chronic denervation with an axonal pattern, and Charcot-Marie-Tooth disease was suspected. Urinary retention had started 3 years previously. Spinal cord magnetic resonance imaging (MRI) showed a lipomeningomye...

Parry Romberg syndrome(PRS) is a rare acquired poorly understood neurocutaneous syndrome of unknown etiology characterized by slow progressive atrophic changes commonly affecting one half of the face. The exact incidence and etiology towards the syndrome remains unclear. Apart from the multifactorial etiology proposed, the possible primary cause is mainly attributed to the cerebral disturbance ...

abstract background glucantime is the first line agent for treatment of cutaneous leishmaniasis (cl). it has adverse effects on blood elements. this research has been done to evaluate the blood complications of this medicine in patients with cutaneous leishmaniasis. methods this clinical trial was done at nikpour clinic, yazd, iran. blood samples were collected from patients diagnosed with cl b...

background: cutaneous leishmaniasis is an endemic disease in many regions of iran, including the city of mashhad. in recent years, some cases have not responded to glucantime, the usual treatment for this disease. the cellular immune response caused by t-helper type 1 (th1) cells has an important role in protection against leishmaniasis, and activation of the t-helper type 2 (th2) response caus...

A plethora of soft tissue fillers have been developed within the past decade to correct the cutaneous changes that occur with photoaging. Such fillers, whether nonpermanent, semipermanent, or permanent, are widely used to fill undesired facial rhytides. In addition, fillers are employed to correct atrophy of the face as well as other parts of the body such as the dorsum of the hands through vol...

© 2015 The Authors. doi: 10.2340/00015555-1908 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Porokeratosis (PK) is a disorder of clonal hyperproliferation of keratinocytes. It has several clinical manifestations characterised by variably sized papules or plaques with a fine peripheral keratotic rim and central atrophy accompanied by a histological finding of cornoid lame...

Cutis marmorata telangiectatica congenita (CMTC) is a very rarely occurring congenital disorder with persistent cutis marmorata, telangiectasia, and phlebectasia. This disorder may be associated with cutaneous atrophy and ulceration of the involved skin. We herewith report a 20-year-old female patient with CMTC since childhood along with ulcerations on both breasts. CMTC is a benign vascular an...

We report on a 59-year-old man with a 1-year history of forearm erythema, bilateral limb arthralgia, and muscle weakness. During the initial examination we observed infiltrative erythema of the forearm and muscle weakness and atrophy of the limbs. Blood tests revealed marked increases in myogenic enzymes. Because histopathological studies showed lymphocytic infiltration around the small blood v...

We report here two cases of vitiligo vulgaris successfully treated with the combination therapy of topical steroid and vitamin D3 compound and currently maintained by vitamin D3 analog without any adverse effects: skin atrophy, striae or telangiectasia on the exposed areas. The best-known mechanism of topical vitamin D3 analog is the enhancement of keratinocytes differentiation and anti-prolife...

BACKGROUND Discoid lupus erythematosus (DLE) is a chronic, disfiguring disease that is characterized by scaly, erythematous, disk-shaped patches and plaques followed by atrophy, scarring, and dyspigmentation. It is refractory to standard therapies in a small population of patients. We investigated the use of lenalidomide, a thalidomide analogue, as a novel alternative therapy in 2 cases of refr...