Metadata is the key to component-based programming. Metadata can provide additional information for every type and member defined in the program code in a languageneutral fashion. Moreover, metadata facilitates the interaction of a component with another component or application. In this position paper, we analyze the expressive power of custom attributes, one of the most innovative features of...

Modern program analysis and model-based tools are increasingly complex and multi-faceted software systems. However, at their core is invariably a component using a logic for describing states and transformations between system states. Logic inferences engines are then critical for the functionality of these systems. A commonly adapted approach has been to use a custom solver, built and tailored...

Fast optimization of CMOS circuits is needed to reduce design cycle time and chip cost and to enhance yield. Mature electronic design automation (EDA) tools and well-defined abstraction-levels for digital circuits have largely automated the digital design process. However, analog circuit design and optimization is still not automated. Custom design of analog circuits and slow analog in SPICE ha...

Background: High throughput sequencing (HTS) has become one of the primary experimental tools used to extract genomic information from biological samples. Bioinformatics tools are continuously being developed for the analysis of HTS data. Beyond some well-defined core analyses, such as quality control or genomic alignment, the consistent development of custom tools and the representation of seq...

Relational databases provide significant flexibility to organize, store, and manipulate an infinite variety of complex data collections. This flexibility is enabled by the concept of relational data schemas, which allow data owners to easily design custom databases according to their unique needs. However, user interfaces and information visualizations for accessing and utilizing databases have...

Power-based side channel attacks are a significant security risk, especially for embedded applications. To improve the security of such devices, protected logic styles have been proposed as an alternative to CMOS. However, they should only be used sparingly, since their area and power consumption are both significantly larger than for CMOS. We propose to augment a processor, realized in CMOS, w...

In just 3 years CRISPR genome editing has transformed biology, and its popularity and potency continue to grow. New CRISPR effectors and rules for locating optimum targets continue to be reported, highlighting the need for computational CRISPR targeting tools to compile these rules and facilitate target selection and design. CHOPCHOP is one of the most widely used web tools for CRISPR- and TALE...

| EEcient use of an optimized custom memory hierarchy to exploit temporal locality in the data accesses can have a very large impact on the power consumption in data dominated applications. In the past experiments have demonstrated that this task is crucial in a complete low-power memory management methodology. But eeective formalized techniques to deal with this speciic task have not been addr...