INTRODUÇÃO: A síndrome de Cushing é um conjunto sinais e sintomas causados pela exposição excessiva a corticoides endógenos ou exógenos, podendo variar entre primária secundária. causa mais comum idiopática, pelo uso desconhecido indiscriminado corticoides, como automedicação; OBJETIVO: Revisão narrativa artigos referente fisiopatologia da Cushing, para simplificação do conhecimento identificaç...

Pendahuluan : Kortikosteroid merupakan salah satu contoh golongan obat yang sering digunakan oleh masyarakat luas. Obat tersebut cukup digemari karena memiliki efek menghambat gejala dari suatu penyakit, sehingga seringkali disebut sebagai dewa. Biasanya kortikosteroid juga diresepkan dokter di rumah sakit terapi beberapa jenis penyakit. Namun, jika dalam jangka waktu lama dan dosis tidak tepat...

The authors report the outcomes from pivotal phase 3 trial in patients with Cushing’s disease of osilodrostat (a potent oral inhibitor cytochrome P450 11B1, [mitochondrial 11β-hydroxylase]). Twice-daily rapidly reduced mean 24-h urine free cortisol (UFC) and sustained this reduction alongside improvements clinical signs hypercortisolism.

What Causes the Acute Blood Pressure Elevation After Stroke? To the Editor: In an insightful editorial1 to a recently published paper by Mattle et al,2 Lindsberg raises a central question as to why blood pressure increases in the acute phase of stroke. The Cushing reflex is suggested as a possible mechanism because it results in sympathetic nervous system activation; however, this reflex is typ...

Adrenal cortical tumors constitute a heterogeneous group of neoplasms with distinct clinical, morphological, and molecular features. Recent discoveries of specific genotype-phenotype correlations in adrenal cortical adenomas have transformed our understanding of their respective endocrine syndromes. Indeed, a proportion of patients with primary aldosteronism are now known to harbor adrenal cort...

Pituicytoma is a rare, low-grade glial neoplasm that arises in the neurohypophysis or infundibulum and usually presents as pituitary gland enlargement. They are often misdiagnosed as pituitary adenomas. Causes have varied for high serum adrenocorticotropic hormone level reported in a few patients with pituicytoma.We report a rare case of pituicytoma accompanied by corticotroph hyperplasia-a cha...

Principles of penetrating head trauma management were established by Harvey Cushing in relation to the management of penetrating brain injuries of World War One. Cushing radically debrided the scalp and skull and aggressively irrigated wound tracks to remove foreign bodies. He would then obtain water-tight closure. Cushing significantly decreased infection rates which reportedly limited the maj...

What Causes the Acute Blood Pressure Elevation After Stroke? To the Editor: In an insightful editorial1 to a recently published paper by Mattle et al,2 Lindsberg raises a central question as to why blood pressure increases in the acute phase of stroke. The Cushing reflex is suggested as a possible mechanism because it results in sympathetic nervous system activation; however, this reflex is typ...

CONTEXT Cushing Syndrome is difficult to diagnose, and the comorbidities and persistent late effects of hypercortisolemia after treatment of the primary disease are challenging for the patient and the endocrinologist. OBJECTIVE To report the case of a girl with obesity and hypertension, ultimately diagnosed with Cushing syndrome due to primary pigmented nodular adrenocortical disease. In this...

Cushing's syndrome is accompanied by many different skin symptoms. A case of a 43-year-old female patient with unrecognized adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome is reported. Besides numerous skin lesions, the patient presented with a rapidly progressive leg ulcer due to venous thrombosis. The initial skin symptoms appeared on her lower leg one month prior to admission. ...