To explore the potential metabolites from rabeprazole sulfide, seven strains of filamentous fungi were screened for their biotransformation abilities. Among these strains, Cunninghamella blakesleeana 3.970 exhibited best result. Four different culture media in order to identify most optimal subsequent research. Single factors such as initial pH media, time, inoculation volume, and volume indivi...

Fungi (Rhizopus stolonifer, Trichoderma viride, Fusarium oxysporum f. sp. conglutinans, Cunninghamella echinulata, and several species of Aspergillus and Penicillium) tolerated higher concentrations of cadmium (Cd) when grown in soil than when grown on laboratory media, indicating that soil mitigated the toxic effects of Cd. In soil amended with clay minerals, montmorillonite provided partial o...

1. When (+/-)-8-aza-d-homo-oestrone 3-methyl ether was added to a culture of Aspergillus ochraceus, the laevo-rotatory enantiomer is reduced to a 17A alcohol. Thus (+/-)-8-aza-d-homo-oestrone 3-methyl ether has been resolved into both its components, the laevo-rotatory enantiomer being obtained by chromic acid oxidation of the alcohol, and the dextro-rotatory enantiomer as residual precursor fr...

Specific inhibitors of Cytochrome P4502C9 enzyme (CYP2C9) viz. clopidogrel, fenofibrate fluvoxamine and sertraline at concentration of 50, 100, 150 and 200 µM were employed to investigate the nature of enzyme involved in bioconversion of meloxicam to its main metabolite 5-OH methyl meloxicam by Cunninghamella blakesleeana. Virtual screening for interaction of specific CYP2C9 inhibitors with hum...