Entamoeba histolytica is a significant cause of morbidity and mortality worldwide. The serine-rich E. histolytica protein (SREHP) is a surface-expressed trophozoite protein that includes multiple hydrophilic tandem repeats. A purified fusion protein between the dodecapeptide repeat of SREHP and cholera toxin B subunit (CTB) has previously been shown to be immunogenic in mice after oral inoculat...

A dramatic bradycardia is induced by underwater submersion in vertebrates. The location of parasympathetic preganglionic cardiac motor neurons driving this aspect of the diving response was investigated using cFos immunohistochemistry combined with retrograde transport of cholera toxin subunit B (CTB) to double-label neurons. After pericardial injections of CTB, trained rats voluntarily dove un...

We tested the hypothesis that application of the subunit B of cholera toxin (CTB) to the airway mucosa would produce labeling of neuronal somata and sensory fibers in the medulla oblongata. Using (125)I-CTB as a tracer, we demonstrated first that CTB is transported across the tracheal epithelium, but once in the airway wall, it remains confined to the subepithelial space and lamina propria. Des...

The CNh and CTb cell lines are derived from the cerebral cortex of normal and trisomy 16 mice, an animal model of human trisomy 21, Down syndrome (DS), and represent in vitro models to study cellular events associated with the human condition. Amyloid precursor protein (APP) plays an important role in the development of neuropathology associated with DS and cholesterol in the amyloidogenic proc...

The placenta is a transient organ that is necessary for proper fetal development. Its main functional component is the trophoblast, which is derived from extra-embryonic ectoderm. Little is known about early trophoblast differentiation in the human embryo, owing to lack of a proper in vitro model system. Human embryonic stem cells (hESCs) differentiate into functional trophoblast following BMP4...

On March 31, 2020, an Mw 6.5 earthquake struck near Stanley, Idaho. More than 35% nondouble-couple component in long-period point-source solutions indicate a more complex source slip on planar fault. Using integrative analysis of seismological and geodetic data, we find that the Stanley ruptured pair opposing-dip faults offset by 10-km-wide step, including unmapped northern subfault with predom...

Cutaneous tuberculosis (cTB) represents 1-2% of extrapulmonary [1] and is caused by the Mycobacterium tuberculosis complex (M. tuberculosis, M. bovis, africanum, microti, canetti, caprae, pinnipedii).

Japanese encephalitis virus (JEV) is an enveloped icosahedral capsid with a prime neutralizing epitope present in E protein domain III (EDIII). dimers are rearranged into five-fold symmetry of icosahedrons. Cholera toxin B (CTB) and heat-labile enterotoxin (LTB) AB5-type was used as the structural scaffold for emulating pentameric axis EDIII. We produced homo-pentameric EDIII through genetic fu...

background: ct scan and nuclear medicine exams deliver a great part of medical exposures. this study examined professional radiation hazards in ct scan and nuclear medicine workers.   methods : in a cross sectional study 30 occupationally exposed workers and 7 controls (all from personnel of a laboratory) were selected. physical dosimetry was performed for exposed workers. blood samples were ob...