OBJECTIVE Intravenous infusion of crystalloid solutions is a cornerstone of the treatment of hemorrhagic shock. However, crystalloid solutions can have variable metabolic acid-base effects, perpetuating or even aggravating shock-induced metabolic acidosis. The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different cryst...

OBJECTIVES To determine the effects of pump priming fluid choice on platelets, fluid balance, and clinical outcomes. DESIGN Meta-analysis of controlled clinical trials. Primary endpoints were platelet counts, colloid oncotic pressure, on-bypass fluid balance, postoperative weight gain, and colloid usage. SETTING Cardiac surgery with cardiopulmonary bypass. PATIENTS Adult and pediatric pat...

Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid-a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony-is dependent on the precisely timed expression of the S-acyl-transferase ...

Cold crystalloid cardioplegia is clinically used since the mid-1960s. It is currently applied in adult and pediatric cardiac surgery patients and remains the preferred method of myocardial protection for many cardiac surgeons. This chapter gives a brief overview about the technical aspects of cold crystalloid cardioplegia application in the operating room.

Gish Biomedical has designed a blood cardioplegia delivery system (MyoManager) which is purported to provide rapid control of blood and crystalloid solution ratios for myocardial preservation. The present study was designed to evaluate the ability of this device to provide cardioplegia solutions of specific hematocrit and potassium ion concentrations ([K+]). An in vitro circuit was designed whe...

Objectives: The current study aimed to investigate the effect of fibrinogen compared fresh frozen plasma (FFP) on outcomes patients with traumatic hemorrhagic shock (THS). Methods: In this double-blind RCT study, chronic diseases referred emergency department (ED) were evaluated. Patients randomly divided into three equal groups; first group received concentrate (70 mg/kg), second was treated F...

BACKGROUND Fluid resuscitation is a crucial therapy for sepsis, and the use of balanced fluids and/or isotonic albumin may improve patient survival. We have previously demonstrated that resuscitation with normal saline results in increased hepatic leukocyte recruitment in a murine model of sepsis. Given that clinical formulations of albumin are in saline, our objectives were to develop a novel ...

Background: Dengue hemorrhagic fever (DHF) occurs due to plasma leakage increased vascular permeability, which is also supported by an active complement system, makes DHF fall into complications such as shock or dengue syndrome (DSS). The comprehensive management of DSS could prevent morbidity and mortality in patients. We aimed report three variations cases their management. Case presentation:...

BACKGROUND The volume of resuscitation in burn patients has been shown to correlate with intra-abdominal pressure (IAP). Limiting volume may reduce consequences of IAP and abdominal compartment syndrome. Colloid resuscitation has been previously shown to limit the volume required initially after burn. METHODS Thirty-one patients were prospectively followed. Inclusion criteria were a burn of 2...