نتایج جستجو برای: crospovidone

تعداد نتایج: 149  

Journal: :Current research in pharmaceutical sciences 2023

A potent non-sulfhydryl prodrug, trandolapril is transformed into the active substance, trandolaprilat, in liver. For obese individuals with mild-to-moderate essential hypertension, Trandolapril effective and safe. The elimination t1/2 of trandolaprilat are approximately 6 hours 16–24 hours, respectively. goal present work to develop immediate release tablet using various superdisintegrants. Cr...

Journal: :Pakistan journal of pharmaceutical sciences 2016
Tazeen Husain Muhammad Harris Shoaib Rabia Ismail Yousuf Madiha Maboos Madeeha Khan Lubna Bashir Shazia Naz

The objective of the present work was to develop Immediate Release (IR) tablets of Metoprolol Tartrate (MT) and to compare trial formulations to a reference product. Six formulations (F1-F6) were designed using central composite method and compared to a reference brand (A). Two marketed products (brands B and C) were also evaluated. F1-F6 were prepared with Avicel PH101 (filler), Crospovidone (...

2012
M. M. Varma Razia Begum

Carbamazepine is a water-insoluble antiepileptic drug. Being a BCS class-II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Crospovidone and croscarmellose sodium were used as the hydrophilic carriers. Solid dispersions showed a remarkable enhancement in the dissolution rate of the drug. In the present research work,...

2017
Vaishali Tejas Thakkar Amol Deshmukh Lal Hingorani Payal Juneja Lalji Baldaniya Asha Patel Tosha Pandya Mukesh Gohel

INTRODUCTION The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. OBJECTIVE Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cy...

Journal: :Chemical & pharmaceutical bulletin 2009
Rajeev Garg Ghanshyam Das Gupta

The present study performed by preparation and evaluation of floating tablets of Silymarin as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, psyllium husk, swelling agent as crospovidone and microcrystalline cellulose and gas generating agent like sodium bicarbonate ...

2016
ARTI MOHAN G. SANGEETHA

Objective: Investigation of in vitro/in vivo behaviour of fast-dissolving tablets containing solid dispersions of oxcarbazepine is the focus of the present research work. Methods: The effect of various hydrophilic polymers on the aqueous solubility of oxcarbazepine was studied. Polyethylene glycol 6000 carrier was selected and solid dispersions were prepared by various methods. A total of nine ...

2015
Harika Ryakala S. Dineshmohan Alluri Ramesh V. R. M. Gupta

Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was...

2012
Rakesh Kumar Bhasin Pradip Kumar Ghosh

Ondansetron is the first of a new class of drugs, selective serotonin receptor antagonist (5 hydroxy tryptamine type 3) used as an anti emetic associated with cancer chemotherapy. Its Orally Disintegrating Tablet has been developed for patients who find swallowing difficult by freeze dried technology by RP Scherer Corporation and Scherer DDS. The aim of this study was to design a new orally dis...

Journal: :International journal of pharmaceutics 2013
Yasunori Iwao Shoko Tanaka Takeaki Uchimoto Shuji Noguchi Shigeru Itai

With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch gly...

2012
M. C. Gohel T. M. Patel R. K. Parikh P. B. Parejiya B. S. Barot A. Ramkishan

The aim of this investigation was to develop a novel multifunctional co-processed diluent consisting of microcrystalline cellulose (Avicel PH 102), crospovidone (Polyplasdone XL) and polyethylene glycol 4000. Colloidal silicon dioxide and talc were also incorporated as minor components in the diluent to improve tableting properties. Melt granulation was adopted for preparation of co-processed d...

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