Corticotropin releasing factor (CRF) dysregulation is implicated in mood and anxiety disorders such as posttraumatic stress disorder (PTSD). CRF is expressed in areas engaged in fear and anxiety processing including the central amygdala (CeA). Complicating our ability to study the contribution of CRF-containing neurons to fear and anxiety behavior is the wide variety of cell types in which CRF ...

cAMP-response element binding (CREB) proteins are involved in transcriptional regulation in a number of cellular processes (e.g., neural plasticity and circadian rhythms). The CREB family contains activators and repressors that may interact through positive and negative feedback loops. These loops can be generated by auto- and cross-regulation of expression of CREB proteins, via CRE elements in...

Abstract STUDY QUESTION What is the transcriptome signature associated with poor performance of rescue IVM (rIVM) oocytes and how can we rejuvenate them? SUMMARY ANSWER The GATA-1/CREB1/WNT signalling axis was repressed in rIVM oocytes, particularly those quality; restoration this may produce more usable oocytes. WHAT IS KNOWN ALREADY aims to mature (MII) for IVF through immature collected from...

Plant and animal populations can adapt to prolonged environmental changes if they have sufficient genetic variation in important phenological traits. The regulation of annual cycles be studied either via candidate genes or through the decomposition phenotypic variance by quantitative genetics. Here, we combined both approaches study timing migration a long-distance migrant, collared flycatcher ...