INTRODUCTION A systematic bias against women, resulting from the use of creatinine as a measure of renal function, has been identified in Model for End-stage Liver Disease (MELD)-based liver allocation. Correction of this bias by calculation of female creatinine levels using the Modification of Diet in Renal Disease (MDRD) formula has been suggested. MATERIAL AND METHODS A cohort of 639 cirrh...

In renal clinical trials, both slope-based and time-to-event renal outcomes have been used. These outcomes are typically based on estimates of GFR obtained using creatinine or iothalamate GFR (iGFR). The African American Study of Kidney Disease and Hypertension (AASK) was a trial in 1094 African Americans with hypertensive nephrosclerosis, which examined the effects of two levels of BP control ...

Polyoma virus nephropathy occurs in 3% to 4% of renal transplant recipients, causing graft loss in 50% of cases. The objective of the present study was to explore the effects of age, sex, post-transplantation period and plasma creatinine levels on the polyoma virus infection in kidney transplanted patients. Urine samples were collected from 362 patients, centrifuged and microscopic slides prepa...

Objective(s):To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. Materials and Methods: Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum a...

Abstact：objective To investigate acute kidney injury (AKI) in children with acute lymphoblastic leukemia (ALL) who received high dose methotrexate (MTX) chemotherapy and explore the corresponding treatment. Methods 180 children who received high dose MTX chemotherapy were observed with serum MTX concentration and serum creatinine. Patients with AKI of stage 3 or poor response to conventional tr...

Background and Objective: Acrylamide is a highly soluble, widely- produced industrial and cytotoxic material. Some substances with antioxidant properties can ameliorate the deleterious effect of acrylamide. Vitamin C is necessary for the normal functioning of all cells and scavenging the free radicals due to the antioxidant properties. The present study was aimed to evaluate the effect of vitam...

Several cephalosporin antibioticscephalothin, cephaloglycine, cephaloridine, cephacetrile, and cefoxitinreportedly interfere positively with measurement of creatinine by the Jaff#{233} reaction. Others such as cefazolin, cephalexin, cephradine, cefamandole, and cephalpirin give negative or only very slight responses under the same in vitro conditions (1, 2). Rankin et al. (3) showed in vivo int...