BACKGROUND Serologic diagnosis of Chlamydophila pneumoniae (Cpn) infection routinely involves assays for the presence of IgG and IgM antibodies to Cpn. Although IgA antibodies to Cpn have been found to be of interest in the diagnosis of chronic infections, their significance in serological diagnosis remains unclear. The microimmunofluorescence (MIF) test is the current method for the measuremen...

OBJECTIVE To investigate the antigenic effect of a peptide containing two epitopes of Chlamydia pneumoniae (Cpn) on atherosclerotic lesion formation in mice infected with Cpn. MATERIALS AND METHODS Six-week-old Apob(tm2Sgy)Ldlr(tm1Her)/J mice were immunized using a repetitive immunization multiple-sites strategy with KLH-conjugated peptides derived from the major outer membrane protein and th...

• Celiac plexus neurolysis (CPN)/celiac plexus block (CPB) is used to treat excruciating cancerrelated abdominal pain.1 • CPN is done via injecting 50%–100% alcohol into the celiac plexus, which is located under the diaphragm at the level of T12-L1 adjacent to the abdominal aorta and the take-off of the celiac trunk.2 • Endoscopic ultrasound guided neurolysis (EUS CPN) has been found to have 85...

Integrated Deterministic and Probabilistic Dependability Analysis (IDPDA) is respectively required for safety properties verification and reliability & availability assessment of critical systems. This paper presents an approach towards IDPDA using Coloured Petri Nets (CPN). Contributions are related to: (a) hierarchical modelling guidelines that cover deterministic and probabilistic features o...

Carboxypeptidase N (CPN) is a plasma zinc metalloprotease comprised of two small subunits that have enzymatic activity, and two large subunits, which protect the enzyme from degradation. CPN cleaves the carboxyl-terminal amino acids arginine and lysine from biologically active peptides such as complement anaphylatoxins, kinins, and fibrinopeptides. To delineate the murine CPN small subunit codi...

Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection. The elderly display an increased susceptibility and severity to this infection. However, the underlying mechanisms are not well understood. Dendritic cells (DCs) are the initiators and regulators of immune responses. Therefore, we investigated the role of DCs in the age-associa...

In Vehicular Ad hoc NETworks (VANETs), trigger-based pseudonym change schemes play an important role in providing anonymity. However, the anonymity provided by these schemes usually is low mainly because the behavior of changing pseudonym is individual. Considering cooperation on changing pseudonym can enhance anonymity, in this paper, we give a general cooperation framework. As an application ...

This dissertation presents the contributions of seven publications all concerned with the application of Coloured Petri Nets (CPN) to requirements modeling for reactive systems. The publications are introduced along with relevant background material and related work, and their contributions to addressing a collection of generic challenges for requirements modeling are discussed. Firstly, two ap...

Chalcones present several biological activities and sulfonamide chalcone derivatives have shown important biological applications, including antitumor activity. In this study, genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of the sulfonamide chalcone N-{4-[3-(4-nitrophenyl)prop-2-enoyl]phenyl} benzenesulfonamide (CPN) were assessed using the Salmonella typhimurium reverse mut...

This paper presents a framework for modelling military operational plans with Coloured Petri Nets (CPN) and its supporting computer tool, Design/CPN. A mapping relationship between key concepts of an operational plan and CPN constructs is established. Parts of an exercise campaign plan were modelled using the proposed framework, and state space analysis of the model conducted to assess operatio...