Ca(2+) is probably the most versatile signal transduction element used by all cell types. In the heart, it is essential to activate cellular contraction in each heartbeat. Nevertheless Ca(2+) is not only a key element in excitation-contraction coupling (EC coupling), but it is also a pivotal second messenger in cardiac signal transduction, being able to control processes such as excitability, m...

Phase-amplitude coupling between theta and multiple gamma sub-bands is a hallmark of hippocampal activity and believed to take part in information routing. More recently, theta and gamma oscillations were also reported to exhibit phase-phase coupling, or n:m phase-locking, suggesting an important mechanism of neuronal coding that has long received theoretical support. However, by analyzing simu...

Coupling in software has been linked with maintainability and existing metrics are used as predictors of external software quality attribute such as fault-proneness, impact analysis, ripple effect of changes, changeability etc. Measurement helps in establishing these factors and hence the quality of a work product. Metric helps in deriving indicators from a collection of measures that can be us...

We study the nature of statistical correlations that develop between systems of interacting self-organized critical automata (sandpiles). Numerical and analytical findings are presented describing the emergence of "synchronization" between sandpiles and the dependency of this synchronization on factors such as variations in coupling strength, toppling rule probabilities, symmetric versus asymme...

There are three key factors in a system of coupled oscillators that characterize the interaction between them: coupling (how to affect), delay (when to affect) and topology (whom to affect). The existing work on each of these factors has mainly focused on special cases. With new angles and tools, this paper makes progress in relaxing some assumptions on these factors. There are three main resul...

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