Vigabatrin was approved for the treatment of infantile spasms by the US Food and Drug Administration, but not in Japan at the time of initiating this clinical study because of concerns about irreversible peripheral visual field defects (VFDs). This study evaluated the efficacy and safety of vigabatrin for Japanese patients with infantile spasms. Of 15 patients (aged ≥4weeks and <2years) enrolle...

Two patients are presented with muscle spasms in an amputation stump. Neither patient experienced neuropathic pain nor phantom sensations, though phantom sensory phenomena, severe pain, and lack of response to treatment is characteristic of reported cases. One patient, a 75 year old man, has had myoclonic activity of the stump for more than two years, and the other, a 79 year old woman, recover...

Determination by radioimmunoassay of corticotropin in the brains of rats, rabbits, dogs, monkeys, and human beings reveals that the dimensions within which the hormone is found is about the same for each of these species but that the anatomical regions in which the hormone is found depends on brain size. Corticotropin is widely distributed in the brain of rats but is found only in the hypothala...

OBJECTIVE To assess the clinical utility and safety of the low-dose corticotropin stimulation test in the diagnosis of secondary adrenocortical insufficiency. DESIGN Prospective study. SETTING Regional hospital, Hong Kong. PARTICIPANTS Seventy-two Chinese patients with suspected secondary adrenocortical insufficiency. MAIN OUTCOME MEASURE Serum cortisol response during the low-dose cort...

A male patient presents with urinary incontinence worsening in the last year, shock sensation, symmetrical weakness and involuntary spasms lower limbs. He currently required double support to ambulate had no sphincter control. Neurological examination demonstrated limb hypertonia spastic paraplegia severe impairment of deep sensation painful muscle spasms. The normal body mass index laboratory ...

Coronary artery spasm, marked by coronary vasoconstriction, is one of the etiologies myocardial ischemia, often presenting as vasospastic angina. Vasospastic angina diagnosed when which predominantly occurs at rest, accompanied ST-segment changes in ECG, or setting borderline ECG changes, a positive provocation test through angiography required. Although spasms could manifest wide clinical sett...

BACKGROUND Pituitary and adrenal responsiveness is suppressed in abstinent alcohol-dependent individuals. To clarify the specific organizational disruption in hypothalamic-pituitary-adrenal functioning during early abstinence, the authors separately assessed each level of the stress-response axis. In this second of a two-part study, ovine corticotropin-releasing factor (oCRH) was used to stimul...