Mast cells (MCs) are a required component of the thymus microenvironment. They affect intercellular interactions and permeability hematothymic barrier through cytokine production. There is speculation that site MCs formation deposition. under complex neuro-endocrine control they can play an important role in process acute transformation stress reaction, affecting extrathymic migration cells. Th...

Magnocellular neurons in the hypothalamic paraventricular nucleus containing arginine vasotocin (AVT) project to the posterior pituitary and release the peptide peripherally to target tissues. Parvocellular neurons contain either corticotropin-releasing hormone (CRH), AVT, or both neuropeptides and project to the median eminence. Corticotropin-releasing hormone and AVT are then transported to t...

A cytosolic peptide activator (Mr approximately equal to 2,200) of cholesterol side-chain cleavage in the adrenal cortex has been isolated from normal corticotropin-treated rats and from rats implanted with the MtT/F4 corticotropin-secreting pituitary tumor. The isolation techniques were those common to peptide hormone purification, including tissue extraction into a highly acidic medium, gel f...

BACKGROUND AND PURPOSE To investigate the incidence, pattern, and magnitude of neuroendocrine changes in long-term survivors of aneurysmal subarachnoid hemorrhage (SAH). METHODS Thirty patients (16 women) with a mean age of 50+/-13 years underwent endocrine assessment between 12 and 24 months after aneurysmal SAH. SAH severity was graded clinically by the Hunt & Hess scale (median, II) and ra...