نتایج جستجو برای: corticosteroid dependent asthma
تعداد نتایج: 762365 فیلتر نتایج به سال:
In a study, published by Bowler et al the Buteyko method was compared with traditional asthma education and general breathing exercises. In both groups the participants were encouraged to use their reliever (beta-agonist) only when asthma symptoms were present. Inhaled preventer (corticosteroid) medicines were gradually reduced if the patient remained stable. Thirty-nine subjects were randomise...
Background—Asthma exacerbations contribute substantially to morbidity, and their reduction is an important therapeutic objective. In this integrated analysis the risk of asthma exacerbations was assessed during treatment with the leukotriene receptor antagonist zafirlukast. Methods—Data were collected from all five double blind, multicentre, randomised, placebo controlled, 13 week trials of zaf...
RATIONALE Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. OBJECTIVES Using transcriptomic profiling of airway tissues, we sought to define the molecular phenotypes of severe asthma. METHODS The transcriptome derived from bronchial biopsies and epithelial brushings of 107 subjects with moderate to severe asthma were annotated by gene set variation...
ATS/ERS statement: asthma control and exacerbations 2 Consistently very poorly controlled asthma increases risk for future severe asthma exacerbations 2 The FDA and safe use of long-acting beta-agonists in the treatment of asthma 2 Thirteen-year follow-up of early intervention with an inhaled corticosteroid in patients with asthma 3 Oral prednisolone for preschool children with acute virus-indu...
BACKGROUND Oral corticosteroids used in short courses for acute asthma are regarded as safe, although the frequent use of these drugs may result in patients suffering from systemic side effects. It has become common practice for patients to increase their own inhaled corticosteroid intake when their asthma goes out of control, but it has never been established whether a high dose of inhaled cor...
Idiopathic chronic eosinophilic pneumonia is a rare and serious disease mostly encountered in female asthmatic patients in their fifth decade of life and rarely in children. Herein, we describe an 11-year-old boy presenting with clubbing of fingers and post-exertional cough without asthma and peripheral eosinophilia. He had had a restrictive pattern in his pulmonary function test that showed ...
BACKGROUND It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma. METHODS We randomly assigned 285 participants two or three years of age with a positive asthma predictive index to treatment with fluticasone propionate (at a dose of 88 mug twice daily) or masked placebo for two years, followed by a one-year ...
In-vitro data suggest that long-acting beta2-agonists may have a neutrophil-stabilising effect. A reduction in airway wall eosinophil number following introduction of salmeterol in persistent asthma has previously been described. There is currently interest in the "neutrophil system" in asthma, and thus the aim of the present study was to investigate the effect of salmeterol on interleukin (IL)...
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