Z. Long, J. B. Murdoch, A. W. Goddard, and U. Dydak School of Health Sciences, Purdue University, West Lafayette, IN, United States, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, Toshiba Medical Research Institute USA, Mayfield Village, OH, United States, Department of Psychiatry, Indiana University School of Medicine, Indi...

A fifteen-year-old girl was treated with isoniazid (INH) for latent tuberculosis infection (LTBI), and subsequently developed epigastric pain, vomiting, and jaundice after three months of treatment. Acute fulminant hepatic failure was diagnosed. INH was stopped, and she received N-acetyl cysteine and Vitamin K. Liver biopsy showed moderate to severe lymphocytic and plasmacytic portal and lobula...

Entorhinal verrucae are unique, small elevations on the surface of entorhinal cortex, formed due to distinctive clustering of large neurons in entorhinal layer II. In Alzheimer’s disease, the verrucae atrophy as a result of neurofibrillary tangle formation and concomitant neuronal loss. Previously, we found significant decreases in verrucae height, width, surface area, and volume even in the mi...

Neuroscience and molecular biology have been generating large datasets over the past years that are reshaping how research is being conducted. In their wake, open data sharing has been singled out as a major challenge for the future of research. We conducted a comparative study of citations of data publications in both fields, showing that the average publication tagged with a data-related term...

In the context of our ongoing search for the neuronal correlates of consciousness (Crick and Koch, 1998, 1999), I discuss Jackendoff’s „Intermediate Level Theory of Consciousness“ as well as related work of others, that implies that we are not directly conscious of our thoughts. I apply this hypothesis to the visual system of the macaque monkey and discuss possible experimental tests.

Although disease hosts are classically assumed to interact randomly [1], infection is likely to spread across structured and dynamic contact networks [2]. We used social network analyses to investigate contact patterns of group-living European badgers, Meles meles, which are an important wildlife reservoir of bovine tuberculosis (TB). We found that TB test-positive badgers were socially isolate...

We investigated whether synchrony between neuronal spike trains is affected by the animal's attentional state. Cross-correlation functions between pairs of spike trains in the second somatosensory cortex (SII) of three macaque monkeys trained to switch attention between a visual task and a tactile task were computed. We previously showed that the majority of recorded neuron pairs (66%) in SII c...

tremely skillful (accurate and quick) in performing learned sequences, not new sequences. Miyashita et al. (1996) found that learned hand movements were led by, and possibly guided by, saccadic eye movements that brought the gaze to the target in an anticipatory 2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421 manner. That eye movement may guide hand movement was also suggested by human studies. Johansson...

While not easily fit into the classic descriptions of the pupillary light reflex, previous studies reported that changes in the spatial composition of the retinal image can evoke a pupillary response. The present study extends this observation by showing that the pupil constricts in response to scotopic as well as photopic spatial patterns. Moreover, the amplitude of the scotopic response decre...