Purpose: To describe a rare bilateral corneal ringshaped opacity, not categorized as corneal dystrophy or degeneration occurring without any associated ocular or systemic disease. Methods: Case report and review of the literature. Results: The authors describe the clinical history and examination of an 80 years old man, with an asymptomatic bilateral and symmetrical ring-shaped corneal opacity ...

PURPOSE To determine the prevalence of keratopathy, cataract, and dry eye in a group of individuals with aniridia. METHODS We reviewed survey data from the Aniridia Foundation International (AFI) registry, which included 99 subjects who self-reported on corneal disease, cataract, and dry eye disease. RESULTS The average age of respondents was 25.3±18.6 years, with a range of 0 to 67. Of 99 ...

Background: The effect of corticosteroid therapy on corneal wound healing is controversial. The objective of this study was to evaluate the effects of combination therapy with dexametha-sone and acetylcysteine at different times and durations on experimentally-induced corneal wounds and haze in rabbits. Methods: Eighteen adult New Zealand white rabbits were divided into three groups of ...

Keratoconus (KC) is a progressive, bilateral, but usually asymmetrical ecstatic corneal disease, characterized by progressive corneal protrusion and thinning, that leads to corneal surface distortion. The reported incidence in the general population varies from 1.3 to 25 per 100,000 per year across different populations, with a prevalence of 8.8–229 per 100,000. Onset typically is at puberty wi...

PURPOSE Amniotic membrane transplantation is currently being used as an alternative approach to treat severe corneal surface disorders refractory to medical therapy. The authors report complications of corneal surface disorders after successful amniotic membrane transplantation. METHODS Case series. RESULTS Twenty-eight patients with corneal surface disorders due to severe chemical burns, c...

Corneal diseases are one of the major causes of blindness worldwide. Conservative medical agents, which may prevent sight-threatening corneal disease progression, are urgently desired. Numerous evidences have revealed the involvement of oxidative stress in various corneal diseases, such as corneal wound healing and Fuchs endothelial corneal dystrophy (FECD). Nuclear factor (erythroid-derived 2)...

PURPOSE To compare the virulence of wild-type Candida albicans strains in a murine model of corneal candidiasis and to investigate the role of fungal filamentation in disease progression. METHODS Scarified corneas of immunocompetent or cyclophosphamide-treated BALB/c mice were topically inoculated with one of three human isolates of C. albicans, a homozygous mutant of the pH-dependent filamen...

IMPORTANCE Corneal transplantation restores visual function when visual impairment caused by a corneal disease becomes too severe. It is considered the world's most frequent type of transplantation, but, to our knowledge, there are no exhaustive data allowing measurement of supply and demand, although such data are essential in defining local, national, and global strategies to fight corneal bl...

Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet's membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress ...