PERFORATING keratoplasty is found to be most successful in cases of small central corneal nebulae and keratoconus. In both these conditions the graft lies completely surrounded by healthy cornea. Where there is gross opacification extending widely throughout the thickness of the cornea and especially if degenerative changes are present, then a simple perforating graft rapidly becomes completely...

PERFORATING keratoplasty is found to be most successful in cases of small central corneal nebulae and keratoconus. In both these conditions the graft lies completely surrounded by healthy cornea. Where there is gross opacification extending widely throughout the thickness of the cornea and especially if degenerative changes are present, then a simple perforating graft rapidly becomes completely...

Biologics, like peptides, proteins and nucleic acids, have proven to be promising drugs for the treatment of numerous diseases. However, besides off label use monoclonal antibody bevacizumab corneal neovascularization, date no other biologics diseases reached market. Indeed, delivering in eye remains a challenge, especially at level cornea. While it appears rather accessible tissue administrati...

Biological soft tissue are of special interest to the researchers as they exhibit unique anisotropic behaviour and are leading contributors to the quality of outcome of a surgical procedure. In this paper attempts have been made to review the strategy adopted by various researchers for conducting experiments in order to understand the mechanical behaviour of cornea and their use in ophthalmolog...

PURPOSE To test the possibility that androgen directly affects the corneal cells, the possible occurrence of androgen receptor (AR) in the cornea and other eye tissues of mice was examined. METHODS To examine the occurrence of AR protein in the mouse eye tissues, an immunocytochemical method was used. To examine the occurrence of AR mRNA in the cornea and lens, reverse transcription-polymeras...

Disease Course Pain is almost always associated with the onset of Mooren’s ulcer. One or both eyes may be involved at either the same time or one following the other. Approximately two thirds of cases affect one eye only. Mooren’s ulcer is more common in men than women. The eye is usually red and the vision may or may not be reduced. Damage begins at the edge of the cornea (near the junction be...

OBJECTIVE To use amniotic membranes as a buffer between the cornea and radioactive eye plaques. METHODS Six melanomas were treated with ophthalmic plaque radiation therapy. Plaque-tumor localization required that a portion of the gold plaque touch the cornea during treatment. To enhance patient comfort and protect the cornea, an (0.1-mm-thick) amniotic membrane was interposed between the meta...

To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour and 4 days after injury. At 7 days after injury, basement membrane regeneration ...

Aim. To report a case of refractory fungal keratitis caused by Scedosporium apiospermum. Methods. Interventional case report. Results. A 47-year-old Malay housewife presented with left eye cornea ulcer as her first presentation of diabetes mellitus. There was no history of ocular trauma, contact lens used, or cornea foreign body. Scedosporium apiospermum was isolated from the cornea scrapping. ...