Transition metal complexes are located at the active sites of a number of enzymes involved in intriguing biochemical reactions. These complexes can exhibit a wide variety of chemical reactivity due to the ease at which transition metals can adopt different coordination environments and oxidation states. Crystallography has been a powerful technique for examining the structure and conformational...

The primary aim of this study was to determine the relationship between certain aspects of coordination, the time course of a bout and sport-related skill levels in cadet judoists. The study evaluated eight judokas with high sport skill levels. Based on the analysis of tournament matches (N=66), the authors determined the activity, effectiveness of actions and the level of achievement. Ten aspe...

The requirement of a divalent metal ion for all enzymatic reactions involving adenosine diand triphosphate is well established, but the role of the metal ion is not clearly understood. In some kinase reactions (1, 2) kinetic evidence has been presented that the metal complex of adenosine triphosphate is the true substrate in the enzymatic reaction. The present study was undertaken to obtain inf...

Nitric oxide (NO) is a promising pharmaceutical agent that has vasodilative, antibacterial, and tumoricidal effects. To study the complex and wide-ranging roles of NO and to facilitate its therapeutic use, a great number of synthetic compounds (e.g., nitrosothiols, nitrosohydroxyamines, N-diazeniumdiolates, and nitrosyl metal complexes) have been developed to chemically stabilize and release NO...

The reaction of silver nitrate and cafenstrole (N,N-diethyl-3-mesitylsulfonyl-1H-1,2,4-triazole-1-carboxamide), a triazole herbicide, leads to the title coordination polymer, [Ag(NO3)(C16H22N4O3S)] n , whose asymmetric unit comprises one cafenstrole ligand mol-ecule, one AgI atom and one nitrate ion. The AgI atom, with a distorted trigonal-pyramidal environment, is coordinated by one nitro-gen ...

In a chemical language, computation is viewed as abstract molecules reacting in an abstract chemical solution. Data can be seen as molecules and operations as chemical reactions: if some molecules satisfy a reaction condition, they are replaced by the result of the reaction. When no reaction is possible within the solution, a normal form is reached and the program terminates. In this article, w...

Spheres of influence: Although cysteine and 3-mercaptopropionate dioxygenase bind react similar substrates, there are key differences in the first- second-coordination spheres that affect their catalytic reaction mechanism reactivity, as highlighted by density functional theory studies on large enzyme clusters.

Many everyday motor tasks have high metabolic energy demands, and some require extended practice to learn the required coordination between limbs. Eight older (73.1 +/- 4.4 years) and 8 younger (23.3 +/- 5.9) men practiced a high-energy two-hand coordination task with both 180 degrees and 90 degrees target relative phase. The older group showed greater performance error in both conditions, and ...

New methods for the synthesis of artificial metalloenzymes are important for the construction of novel biocatalysts and biomaterials. Recently, we reported new methodology for the synthesis of artificial metalloenzymes by reconstituting apo-myoglobin with metal complexes (Ohashi, M. et al., Angew Chem., Int. Ed. 2003, 42, 1005-1008). However, it has been difficult to improve their reactivity, s...

Alzheimer's disease is the most common form of age-related neurodegenerative dementia. The disease is characterised by the presence of plaques in the cerebral cortex. The major constituent of these plaques is aggregated amyloid-β peptide. This review focuses on the molecular aspects of metal complexes designed to bind to amyloid-β. The development of radioactive metal-based complexes of copper ...