This paper reviews some of the challenges faced by individuals who design and implement clinical trials of potential antidepressant medications. Particular emphasis is placed on questioning the validity of some of the theoretical assumptions that form the underpinnings of most conventional trials. Work from our group developing clinical trial methodology for minor depression is used as an examp...

Gastrointestinal (GI) disorders, including functional bowel diseases such as irritable bowel syndrome (IBS) and inflammatory bowel diseases such as Crohnʹs disease (CD) and colitis, afflict more than one in five Americans, particularly women. While some GI disorders may be controlled by diet and pharmaceutical medications, others are poorly moderated by conventional treatments. Symptoms of GI d...

Coronary artery disease is a chronic medical condition associated with high mortality and morbidity. Among individuals with coronary artery disease, more than 50% have chronic stable angina. Recent evidence supports initial treatment with medical therapy, followed by revascularization, if indicated, in patients with chronic stable angina. The successful management of patients with chronic stabl...