BACKGROUND AND OBJECTIVES The discontinuation of drugs such as angiotensin-converting enzyme inhibitors (ACE inhibitors) has been suggested based on reports of hypotension during anesthesia. This may imply on a higher risk of intraoperative hypertensive peaks with deleterious consequences for the patient. The objective of the present study was to evaluate the influence of the preoperative use o...

Controlled hypotension was induced in pigs by the infusion of adenosine, sodium nitroprusside (SNP) or nitroglycerin (TNG). Central and regional haemodynamics were studied using the microsphere technique during control and hypotensive periods. All three drugs produced decreases in mean arterial pressure (MAP), but it was very difficult to maintain stable values of hypotension with TNG, and it w...

Thirty patients undergoing radical surgery for cancer of the head and neck were subjected to deliberate hypotension (60-80 mm Hg) for an average period of 275 minutes. Ten patients undergoing surgery of similar magnitude but without controlled hypotension formed a control group. Hypotensive patients excreted significantly less urine during surgery. There were no discernible differences between ...

This paper describes a simplified technique for biopsy of the retina and choroid which had been used in 5 human volunteers. The biopsy was carried out in 4 immediately before enucleation of an eye for malignant melanoma and in 1 patient who was undergoing trabeculectomy for painful glaucoma associated with retinitis pigmentosa. A combination of intravenous mannitol and transient controlled syst...

The effect of graded, progressive hypotension on the autoregulation of cerebral blood flow was studied in anaesthetised baboons. Progressive hypotension was produced over a period of four to five hours, either by graded haemorrhage or by the administration of increasing concentrations of hypotensive drugs. During haemorrhagic hypotension autoregulation was maintained until the mean arterial pre...

Since 1948 61 patients have been operated on for coarctation of the aorta at the University Hospital, Copenhagen. The technical problems of this operation are largely due to the high blood pressure proximal to the stenosis and in the highly developed and dilated collaterals which are forced to act as a by-pass round the stenosis. These dilated and fragile vessels, particularly the intercostal a...

INTRODUCTION Clevidipine is an ultra-shorting acting, intravenous calcium channel antagonist of the dihydropyridine class. Metabolism by blood and tissue esterases results in a half-life of 1-2 minutes thereby allowing easy titration by i.v. administration. We present preliminary experience with this novel agent to provide controlled hypotension (CH) in a cohort of adolescents undergoing poster...