Regulatory changes are transforming the multitrillion dollar swaps market from a network of bilateral contracts to one in which swaps are cleared through central counterparties (CCPs). The stability of the new framework depends on the CCPs’ resilience. Margin requirements are a CCP’s first line of defense against the default of a counterparty. To capture liquidity costs at default, margin requi...

The present study describes the implementation of a food safety system in a dairy processing plant located in the State of São Paulo, Brazil, and the challenges found during the process. In addition, microbiological indicators have been used to assess system's implementation performance. The steps involved in the implementation of a food safety system included a diagnosis of the prerequisites, ...

Cells with motile cilia cover the skin of Xenopus tadpoles in a characteristic spacing pattern. This pattern arises during early development when cells within the inner layer of ectoderm are selected out by Notch to form ciliated cell precursors (CCPs) that then radially intercalate into the outer epithelial cell layer to form ciliated cells. When Notch is inhibited and CCPs are overproduced, r...

Endocytic internalization of G protein-coupled receptors (GPCRs) plays a critical role in down-regulation of GPCR signaling. The yeast mating pheromone receptor Ste2p has been used as a model to investigate mechanisms of signal transduction, modification, and endocytic internalization of GPCRs. We previously used a fluorescently labeled mating pheromone derivative to reveal unappreciated molecu...

Multivariate control charts such as Hotelling`s T^ 2 and X^ 2 are commonly used for monitoring several related quality characteristics. These control charts use correlation structure that exists between quality characteristics in an attempt to improve monitoring. The purpose of this article is to discuss some issues related to the G chart proposed by Levinson et al. [9] for detecting shifts in ...

identification of a real time of a change in a process, when an out-of-control signal is present is significant. this may reduce costs of defective products as well as the time of exploring and fixing the cause of defects. another popular topic in the statistical process control (spc) is profile monitoring, where knowing the distribution of one or more quality characteristics may not be appropr...

BanK oF canaDa FinanciaL SYStem reVieW JUne 2011 Broad access to central clearing will be necessary to fully realize the expected benefits of systemic-risk reduction from the increased use of ccPs . the evolving configuration of access to ccPs may, however, have unintended consequences for the structure of the global otc derivatives market . as the use of ccPs is mandated or strongly encouraged...

Identification of the assignable causes of process variability and the restriction and elimination of their influence are the main goals of statistical process control (SPC). Identification of these causes is associated with so called tests for special causes or runs tests. From the time of the formulation of the first set of such rules (Western Electric rules) several different...

Control chart is the most well-known chart to monitor the number of nonconformities per inspection unit where each sample consists of constant size. Generally, the design of a control chart requires determination of sample size, sampling interval, and control limits width. Optimally selecting these parameters depends on several process parameters, which have been considered from statistical and...