BACKGROUND Excessive air pollution in urban environments can impact morbidity and mortality. The authors evaluated the role of particulate matter2.5 (PM2.5) in structural, geometric, and functional remodeling in hearts, using an experimental model of myocardial infarction. METHODS AND FINDINGS Seventy-five rats were divided into 5 groups: control (CG), CG exposed to PM2.5 pollution (CGP), myo...

Mitochondria constantly divide (mitochondrial fission) and fuse (mitochondrial fusion) in a normal cell. Disturbances in the balance between these two physiological processes may lead to cell dysfunction or to cell death. Induction of cell death is the prime goal of prostate cancer chemotherapy. Our previous study demonstrated that androgens increase the expression of a mitochondrial protein in...

Background and aims—The subtype and species related heterogeneity of â adrenoceptors prompted a functional reappraisal of these molecular targets of motility inhibition in the human colon. Methods—Relaxation of muscle strips was measured in vitro. Results—The following agonists had decreasing relaxing potency (eVective concentration range 10–10 mol/l): (−)isoprenaline (non-selective), terbutali...

The microbial alkaloid Staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been shown to exert a high degree of selectivity for inhibition of protein kinase C activity. Both compounds are powerful inhibitors of proliferation of both normal and transformed cells in vitro and exert antitumor efficacy in vivo. In this work we have studied the mode ...

Full synchronization (FS) leaf sequencing removes tongue-and-groove underdosages (TGU) but increases the number of segments. Constrained partial synchronization (CPS) uses a minimum tongue-and-groove ratio (TGR) to reduce the number of segments while achieving acceptable TGUs. TGR is the ratio of non-overlapping intensities that irradiate a common junction. For TGRs of 1, 1.5 and 2, the TGUs we...

In this paper, a preliminary investigation of Cartesian Genetic Programming (CGP) for algorithmic intraday trading is conducted. CGP is a recent new variant of genetic programming that differs from traditional approaches in a number of ways, including being able to evolve programs with limited size and with multiple outputs. CGP is used to evolve a predictor for intraday price movements, and tr...

The modeling and prediction of functions that can exhibit non-stationarity characteristics is important in many applications; for example, this often the case simulator output. One approach to predict a function with unknown stationarity properties model it as draw from flexible stochastic process produce stationary or non-stationary realizations. such composite Gaussian (CGP) which expresses l...

Layered Ti-Al metal composite (LMC) fabricated by hot-pressing and hot-rolling process displays higher ductility than that of both components. In this paper, a combination of digital image correlation (DIC) and X-ray tomography revealed that strain delocalization and constrained crack distribution are the origin of extraordinary tensile ductility. Strain delocalization was derived from the tran...

CGP

background: prevention of slipping accidents requires provision of adequate friction through the use of suitable combinations of footwear and underfoot surfaces. shoe sole tread groove is one of the important factors on friction coefficient during walking. objective: to measure the effect of different shoe sole tread groove depths and different surfaces on the required quotient of friction (q),...