Meiotic recombination, crucial for proper chromosome segregation and genome evolution, is initiated by programmed DNA double-strand breaks (DSBs) in yeasts and likely all sexually reproducing species. In fission yeast, DSBs occur up to hundreds of times more frequently at special sites, called hot spots, than in other regions of the genome. What distinguishes hot spots from cold regions is an u...

We present a technique for creating a longitude-resolved image of Jupiter’s thermal radio emission. The technique has been applied to VLA data taken on 25 January 1996 at a wavelength of 2 cm. A comparison with infrared data shows a good correlation between radio hot spots and the 5 μm hot spots seen on IRTF images. The brightest spot on the radio image is most likely the hot spot through which...

Bone scintigraphy is widely used to detect bone metastasis owing to its high sensitivity, but solitary focus of increased uptake often causes diagnostic problem because of its low specificity. The purpose of this study was to assess the significance of solitary hot spot detected in patients with extraskeletal malignancies. We reviewed 1,167 consecutive bone scintigraphies of patients with histo...

MOTIVATION Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy. These residues are critical in understanding the principles of protein interactions. Experimental studies like alanine scanning mutagenesis require significant effort; therefore, there is a need for computational methods to predict hot spots in protein interfac...

background and aims: one of the most common approach to understanding spatial and temporal trends of event data is to break it up into a series of time snapshots. therefore space-time cube method applied in order to portray the likely trend in occurrence of the pulmonary tuberculosis (tb) cases. methods: in this study, information of all patients with pulmonary tb recorded in surveillance syste...

Highly prized is the truly productive crime prevention strategy, one that lightens the load on an overworked criminal justice system and, more importantly, reduces the number of victims. But to prevent crimes—especially in hot spots (high-crime areas)—police must determine where and when crimes are likely to occur. Drawing primarily on data collected in the United Kingdom, this Research in Acti...

Fumaroles (steam vents) are the most common, yet least understood, microbial habitat in terrestrial geothermal settings. Long believed too extreme for life, recent advances in sample collection and DNA extraction methods have found that fumarole deposits and subsurface waters harbor a considerable diversity of viable microbes. In this study, we applied culture-independent molecular methods to e...