Although generally a sporadic disease, a few cases of Guillain Barre syndrome clustered in families have been reported. We describe four siblings of a Pakistani family from a consanguineous marriage out of whom two developed definite GBS and two had probable GBS at different times. This suggests that there may be a genetic element in the pathogenesis of at least some forms of Guillain Barre syn...

A 14 year male adolescent born of 2nd degree consanguineous marriage presented with asymptomatic proteinuria and severe anemia. He had leucopenia, anisopoikilocytosis, megaloblastic erythropoiesis, megakaryocytes with low serum B12 level. His younger sibling was similarly affected. This combination suggested Imerslund-Grasbeck syndrome. The hemoglobin levels improved with injection of vitamin B...

J Postgrad Med 2004;50:125-6 n 18-month-old female child born of a second degree consanguineous marriage presented with asymptomatic, pink, raised lesions on the body since the age of six months and boggy swellings on the scalp since the age of 12 months. There was a gradual increase in the size of the skin and scalp lesions. A progressive, painless, flexion deformity of both the upper and lowe...

A 5-day-old newborn, product of non-consanguineous marriage, presented with inability to completely open oral cavity and feeding difficulty. On examination, there was a good sucking reflex and limited mouth opening (Fig. A) with retrognathia (Fig. B). Maxillary CT with 3D reconstruction revealed hypoplasia of the ascending branches of the mandible; the temporomandibular joints were normal (Fig....

A 8-month-old female baby presented with cushingoid facies, with large skin folds involving the extremities and trunk since birth (Fig. 1). The child was born to healthy parents in a non-consanguineous marriage. The child weighed 8 kgs, was exclusively breast fed and developmentally normal and had no dysmorhic features. There was no history of similar complaints in other family members. Serum c...

Purpose: This study exposes the rate of consanguineous marriages in afghan population and its effects on health their children.
 Methodology: A questionnaire was designed to collect data. total 2300 respondents were asked about socio-demographic attitude towards which 2201 responded according criteria. The paper describes quantitative qualitative types surveys, include field observations d...

During the early years of Christianity there were major social and legal differences in attitude towards consanguineous marriage in the Eastern and Western Roman empires, reflecting pre-existing divisions between the Classical Greek and Roman worlds. In Athens and Sparta first-cousin, uncle–niece and half-sib marriages were permissible, with half-sib marriage, and even full-sib marriage continu...