A 54-year-old African-American woman developed a pigmented papillary squamous cell carcinoma in the palpebral and bulbar conjunctiva of the right eye in areas that received no sun exposure. In situ hybridization performed on the tumor showed human papilloma virus 16. The left eye showed a pedunculated nonpigmented conjunctival dysplasia. The tumors were extirpated by cryosurgery and topical int...

PURPOSE Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior. While CM has a propensity to spread first to regional lymph nodes, UM metastasizes almost exclusively via the hematogenic route to the liver. We investigated whether these different metastatic patterns might be attributable to diffe...

I t has been proposed that ocular surface melanomas should be treated by simple local excision and cryotherapy to the conjunctival borders. Based on what is known of the biology of both cutaneous and mucosal melanomas, however, we consider it unlikely that such a technique, without deep scleral clearance, will reliably eliminate ocular surface melanomas. Indeed, the documented behavior of melan...

Purpose. To assess the conjunctival functionality in a rabbit dry eye (DE) model. Methods. Nictitating membrane, lacrimal and Harderian glands were surgically excised from male New Zealand white rabbits using minimally invasive surgery. Fluorescein/rose Bengal staining of ocular surface (OS) and Schirmer test were done before (BE) and after excision (AE). The expression of interleukin- (IL-) 1β...

PURPOSE To determine the expression and function of toll-like receptors (TLRs) in human conjunctival, limbal and corneal epithelial cells. METHODS Expression of TLRs was examined by real-time polymerase chain reaction, immunohistochemistry, and western blot analysis in human conjunctival, corneal and limbal epithelial cells and tissues. Ligand-stimulated nuclear factor kappaB activation; inte...

Purpose To describe a case of diffuse conjunctival papilloma in an immunocompromised individual on tacrolimus that was refractory to treatment with interferon α-2b, but responded to topical mitomycin-c. Observations A 79-year-old Caucasian female with a history of a liver transplant twenty years ago, who was immunosuppressed with tacrolimus (2 mg daily) presented with a diffuse conjunctival a...

OBJECTIVES To investigate the characteristics and effects of allogenic conjunctiva and conjunctival extracellular matrix (ECM) as the substitute of conjunctival tissues. BACKGROUND The symptoms of the frequently-occurring conjunctival injury not only make people ugly, but also lead to blindness, which seriously endanger the quality of life of the patients. METHODS The bulbar conjunctivas of...

Papillomas of the conjunctival surface in people can be of viral or nonviral origin and are found in high association with human papillomavirus. Canine conjunctival papillomas are seldom described, and published accounts have mostly been associated with canine oral papillomavirus infection. Here, we describe conjunctival squamous papillomas that do not express papillomavirus proteins and compar...

Aims: To describe the results of a study of the incidence of conjunctival ulceration and its pathology as a manifestation of Behçet’s syndrome. Methods: The authors reviewed retrospectively medical charts of 152 patients with Behçet’s syndrome seen at the uveitis service of Okayama University Hospital from January 1995 to December 1999. Criteria used to diagnose Behçet’s syndrome in this study ...