Light-mediated coupling of acylsilanes with indoles is reported. This photo click reaction occurs under mild conditions (415 nm) mostly in quantitative yield and provides stable silylated N,O-acetals via light mediated siloxycarbene generation subsequent indole-N-H insertion. We show that this very efficient fully atom economic process can be applied to conjugate complex systems, as documented ...

To achieve a conjugate gradient method which is strong in theory and efficient practice for solving unconstrained optimization problem, we propose hybridization of the Hager Zhang (HZ) Polak-Ribière Polyak (PRP) methods possesses an important property well known PRP method: tendency to turn towards steepest descent direction if small step generated away from solutio...

background and objective: escherichia coli o157:h7, an emerging pathogen, causes severe enteritis and the extraintestinal complication of hemolytic-uremic syndrome. the goal of this study was to evaluate the conjugate of e. coli o157: h7 lipopolysaccharide (lps) with diphtheria toxoid (dt) as a candidate vaccine in mice model. material and methods: lps from e. coli o157:h7 was extracted by hot ...

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...

HE morphogenetic sequence leading to the establishment of the fertile dikaryon from two self-sterile homokaryons in the tetrapolar Hymenomycete Schizophyllum commune consists of a number of distinct stages. After hyphal fusion between compatible homokaryons, (a) reciprocal nuclear exchange and migration convert both homokaryons into a dikaryon by (b) pairing of the compatible nuclei, ( c ) conj...

An octathymidylate covalently linked via its 3'-end to an acridine derivative inhibited the cytopathic effect of Simian Virus SV40 on CV-1 cells in culture. Control experiments revealed that this effect was virus-specific and did not arise as a result of oligonucleotide degradation by nucleases. A photoactive probe was covalently attached to the 5'-end of the oligonucleotide-acridine conjugate....

5-Alkylidenecyclopent-2-enones 15a-q may be prepared via a conjugate addition-Peterson olefination sequence, best achieved in one-pot, using exo-2-trimethylsilyl-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one 12, followed by a retro-Diels-Alder reaction. The geometry of the exocyclic alkene may be controlled according to the use of organometallic species in the conjugate addition step; organocupra...

Reversal of the multidrug-resistant (MDR) phenotype is very important for chemotherapy success. In fact, the expression of the MDR1 gene-encoded P-glycoprotein (P-gp) actively expels antitumor agents such as daunomycin (DNM) out of the cells, resulting in drug resistance. We show that upon conjugation to triplex-forming oligonucleotides, it is possible to address DNM in resistant cells (MCF7-R ...

PREQN is a package of Fortran subroutines for automatically generating pre conditioners for the conjugate gradient method It is designed for solving a sequence of linear systems Aix bi i t where the coe cient matrices Ai are symmetric and positive de nite and vary slowly Problems of this type arise for example in non linear optimization The preconditioners are based on limited memory quasi Newt...

In this paper, we present a formalism for computing the non-vanishing Higgs μterms in a heterotic standard model. This is accomplished by calculating the cubic product of the cohomology groups associated with the vector bundle moduli (φ), Higgs (H) and Higgs conjugate (H̄) superfields. This leads to terms proportional to φHH̄ in the low energy superpotential which, for non-zero moduli expectation...